| Integrating innovative therapeutic strategies into the management of renal cell carcinoma. | |
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MedLine Citation:
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PMID: 22870536 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Three emerging trends have occurred recently in renal cell carcinoma (RCC). First, over the last several decades there has been a marked increase in the diagnosis of RCC, with a corresponding decrease in the typical tumor size, resulting in an increased interest in less invasive approaches to primary tumor treatment. Second, while conventional radiotherapy plays a limited palliative role due to the relative radio-resistance of RCC, advances in immobilization and image guidance have led several investigators to consider stereotactic radiotherapy techniques (SRT) to overcome this resistance, with impressive results in the metastatic setting. In addition, preliminary use of SRT to treat the primary RCC tumor is underway. Thirdly, although RCC is resistant to conventional chemotherapy agents, exciting recent advances have emerged in the treatment of clear cell RCC, with the development of targeted agents in addition to immunotherapy-based treatments. In the current critical review we discuss these emerging trends in localized and systemic treatment as well as possible interesting combinations of the two modalities. Finally, we discuss the role of the new systemic agents in non-clear cell RCC. |
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Authors:
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Janice P Dutcher; Waleed Fouad Mourad; Ronald D Ennis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oncology (Williston Park, N.Y.) Volume: 26 ISSN: 0890-9091 ISO Abbreviation: Oncology (Williston Park, N.Y.) Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-08-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712059 Medline TA: Oncology (Williston Park) Country: United States |
Other Details:
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Languages: eng Pagination: 526-30, 532, 534 Citation Subset: IM |
Affiliation:
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Continuum Cancer Centers of New York, New York, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Comments/Corrections | |
Comment In:
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Oncology (Williston Park). 2012 Jun;26(6):537
[PMID:
22870538
]
Oncology (Williston Park). 2012 Jun;26(6):534, 536 [PMID: 22870537 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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