Document Detail

Integrating clinical pharmacology concepts in individualized therapy with tyrosine kinase inhibitors.
MedLine Citation:
PMID:  23419484     Owner:  NLM     Status:  In-Data-Review    
Tyrosine kinases have emerged as important tumor targets for the design of potent and selective inhibitors. Eighteen of these tyrosine kinase inhibitors (TKIs) have already been approved for the treatment of diseases that were previously essentially resistant to standard chemotherapy. Major efforts are ongoing that focus on the development of companion diagnostics for investigational and approved TKIs, as well as on integrating clinical pharmacology principles in clinical practice to decrease toxicity and improve efficacy.
C D Drenberg; S D Baker; A Sparreboom
Related Documents :
16911524 - Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line lx...
24474794 - Discrete mechanisms of mtor and cell cycle regulation by ampk agonists independent of a...
24910994 - Induction of mitotic catastrophe by pkc inhibition in nf1-deficient cells.
23582444 - Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (ap...
11311144 - Involvement of mitogen-activated protein kinase activation in the signal-transduction p...
15944294 - Structure/function analysis of tristetraprolin (ttp): p38 stress-activated protein kina...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  93     ISSN:  1532-6535     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  AIM; IM    
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mild encephalopathy with splenial lesion and parainfluenza virus infection.
Next Document:  The state of clinical pharmacology today.