| Integrating carbon nanotubes and lipid bilayer for biosensing. | |
| | |
MedLine Citation:
|
PMID: 20047826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Membrane proteins, which are the target of most drugs, are implicated in many critical cellular functions such as signal transduction, bioelectricity, exocytosis and endocytosis. Therefore, developing techniques to investigate the functions of membrane proteins is obviously important. Here, we have developed a novel system by integrating artificial lipid bilayer (biomimetic membrane) with single-walled carbon nanotube networks (SWNT-net) based field-effect transistor (FET), and demonstrated that such hybrid nanoelectronic biosensors can specifically and electronically detect the presence and dynamic activities of ionophores (specifically, gramicidin and calcimycin) in their native lipid environment. This technique can potentially be used to examine other membrane proteins (e.g. ligand-gated ion channels, receptors, membrane insertion toxins, and antibacterial peptides) for the purposes of biosensing, fundamental studies, or high throughput drug screening. |
| | |
Authors:
|
Yinxi Huang; Preeti Vikas Palkar; Lain-Jong Li; Hua Zhang; Peng Chen |
Related Documents
:
|
16216066 - Molecular dynamics simulations of salicylate effects on the micro- and mesoscopic prope... 10465756 - Polymer-cushioned bilayers. ii. an investigation of interaction forces and fusion using... 17173856 - Molecular studies of the gel to liquid-crystalline phase transition for fully hydrated ... 2712306 - Selective electrochemical biosensors from state-switching of bilayer and monolayer lipi... 23676206 - Competing exchanges and spin-phonon coupling in eu1-xrxmno3 (r=y, lu). 12926396 - Kinetics and mechanism of ring transformation of s-[1-(4-methoxyphenyl)pyrrolidin-2-on-... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-23 |
Journal Detail:
|
Title: Biosensors & bioelectronics Volume: 25 ISSN: 1873-4235 ISO Abbreviation: Biosens Bioelectron Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-17 Completed Date: 2010-05-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9001289 Medline TA: Biosens Bioelectron Country: England |
Other Details:
|
Languages: eng Pagination: 1834-7 Citation Subset: IM |
Copyright Information:
|
(c) 2009 Elsevier B.V. All rights reserved. |
Affiliation:
|
School of Chemical and Biomedical Engineering, Bioengineering Division, Nanyang Technological University, 70 Nanyang Drive, Block N1.3, Singapore 637457, Singapore. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biomimetic Materials
/
chemistry* Biosensing Techniques / methods* Conductometry / methods* Lipid Bilayers / chemistry* Membrane Proteins / chemistry* Nanotechnology / methods* Nanotubes, Carbon / chemistry* Systems Integration |
| Chemical | |
Reg. No./Substance:
|
0/Lipid Bilayers; 0/Membrane Proteins; 0/Nanotubes, Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electrochemical detection of vascular endothelial growth factors (VEGFs) using VEGF antibody fragmen...
Next Document: Electrochemical impedance biosensor with electrode pixels for precise counting of CD4(+) cells: A mi...