Document Detail


Integrating automated workflows, human intelligence and collaboration.
MedLine Citation:
PMID:  21347175     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Many methods and tools have evolved for microarray analysis such as single probe evaluation, promoter module modeling and pathway analysis. Little is known, however, about optimizing this flow of analysis for the flexible reasoning biomedical researchers need for hypothesizing about disease mechanisms. In developing and implementing a workflow, we found that workflows are not complete or valuable unless automation is well-integrated with human intelligence. We present our workflow for the translational problem of classifying new sub-types of renal diseases. Using our workflow as an example, we explain opportunities and limitations in achieving this necessary integration and propose approaches to guide such integration for the next great frontier-facilitating exploratory analysis of candidate genes.
Authors:
Barbara Mirel; Felix Eichinger; Viji Nair; Matthias Kretzler
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Publication Detail:
Type:  Journal Article     Date:  2009-03-01
Journal Detail:
Title:  Summit on translational bioinformatics     Volume:  2009     ISSN:  2153-6430     ISO Abbreviation:  Summit on Translat Bioinforma     Publication Date:  2009  
Date Detail:
Created Date:  2011-02-24     Completed Date:  2011-07-14     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101528043     Medline TA:  Summit on Translat Bioinforma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  -    
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Grant Support
ID/Acronym/Agency:
R01 DK079912/DK/NIDDK NIH HHS; R24 DK082841/DK/NIDDK NIH HHS; R24 DK082841-04/DK/NIDDK NIH HHS
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