| Integrating automated workflows, human intelligence and collaboration. | |
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MedLine Citation:
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PMID: 21347175 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Many methods and tools have evolved for microarray analysis such as single probe evaluation, promoter module modeling and pathway analysis. Little is known, however, about optimizing this flow of analysis for the flexible reasoning biomedical researchers need for hypothesizing about disease mechanisms. In developing and implementing a workflow, we found that workflows are not complete or valuable unless automation is well-integrated with human intelligence. We present our workflow for the translational problem of classifying new sub-types of renal diseases. Using our workflow as an example, we explain opportunities and limitations in achieving this necessary integration and propose approaches to guide such integration for the next great frontier-facilitating exploratory analysis of candidate genes. |
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Authors:
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Barbara Mirel; Felix Eichinger; Viji Nair; Matthias Kretzler |
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Publication Detail:
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Type: Journal Article Date: 2009-03-01 |
Journal Detail:
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Title: Summit on translational bioinformatics Volume: 2009 ISSN: 2153-6430 ISO Abbreviation: Summit on Translat Bioinforma Publication Date: 2009 |
Date Detail:
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Created Date: 2011-02-24 Completed Date: 2011-07-14 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 101528043 Medline TA: Summit on Translat Bioinforma Country: United States |
Other Details:
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Languages: eng Pagination: 79-83 Citation Subset: - |
Affiliation:
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School of Education, Univ of Michigan, Ann Arbor, MI. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 DK079912/DK/NIDDK NIH HHS; R01 DK079912-04/DK/NIDDK NIH HHS; R24 DK082841-04/DK/NIDDK NIH HHS |
| Comments/Corrections | |
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