Document Detail


Integrated response of the upper and lower respiratory tract of asthmatic subjects to frigid air.
MedLine Citation:
PMID:  10710402     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the influence of cold air hyperpnea on integrated upper and lower airway behavior, 22 asthmatic volunteers hyperventilated through their mouths (OHV) and noses (NHV) while pulmonary and nasal function were determined individually and in combination. In the isolated studies, OHV at a minute ventilation of 65 +/- 3 l/min lowered the 1-s forced expiratory volume (FEV(1)) 24 +/- 2% (P < 0. 001) and NHV (40 l/min) induced a 31 +/- 9% (P < 0.001) increase in nasal resistance (NR). In the combined studies, oral hyperpnea reduced the FEV(1) (DeltaFEV(1) 26 +/- 2%, P < 0.001) and evoked a significant rise in NR (DeltaNR 26 +/- 9%, P = 0.01). In contrast, NHV only affected the upper airway. NR rose 33 +/- 9% (P = 0.01), but airway caliber did not change (DeltaFEV(1) 2%, P = 0.27). The results of this investigation demonstrate that increasing the transfer of heat and water in the lower respiratory tract alters bronchial and nasal function in a linked fashion. Forcing the nose to augment its heat-exchanging activity, however, reduces nasal caliber but has no effect on the intrathoracic airways.
Authors:
M L McLane; J A Nelson; K A Lenner; R Hejal; C Kotaru; M Skowronski; A Coreno; E Lane; E R McFadden
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  88     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-24     Completed Date:  2000-04-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1043-50     Citation Subset:  IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.
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MeSH Terms
Descriptor/Qualifier:
Acclimatization / physiology
Adult
Air
Airway Resistance / physiology
Asthma / physiopathology*
Body Temperature Regulation / physiology
Bronchi / physiopathology
Cold Temperature / adverse effects
Female
Forced Expiratory Volume / physiology
Humans
Hyperventilation / physiopathology
Male
Nasal Cavity / physiology
Respiratory Mechanics / physiology*
Grant Support
ID/Acronym/Agency:
HL-33791/HL/NHLBI NIH HHS; HL-37117/HL/NHLBI NIH HHS; HL-44920/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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