Document Detail

Integrated multimodal endomicroscopy platform for simultaneous en face optical coherence and two-photon fluorescence imaging.
MedLine Citation:
PMID:  22297353     Owner:  NLM     Status:  MEDLINE    
We report an all-fiber-optic scanning, multimodal endomicroscope capable of simultaneous optical coherence tomography (OCT) and two-photon fluorescence (TPF) imaging. Both imaging modalities share the same miniature fiber-optic scanning endomicroscope, which consists of a double-clad fiber with a core operating in single mode at both the OCT (1310 nm) and two-photon excitation (1550 nm) wavelengths, a piezoelectric two-dimensional fiber-optic beam scanner, and a miniature aspherical compound lens suitable for simultaneous acquisition of en face OCT and TPF images. A fiber-optic wavelength division multiplexer was employed in the integrated platform to combine the low coherence OCT light source and the femtosecond two-photon excitation laser into the same optical path. Preliminary imaging results of cell cultures and mouse tissue ex vivo demonstrate the feasibility of simultaneous real-time OCT and TPF imaging in a scanning endomicroscopy setting for the first time.
Jiefeng Xi; Yongping Chen; Yuying Zhang; Kartikeya Murari; Ming-Jun Li; Xingde Li
Related Documents :
25484943 - A neurosurgical navigation system based on intraoperative tumour remnant estimation.
8892203 - A readout magnet for prepolarized mri.
20442323 - Kinematics of the anterior cruciate ligament during gait.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Optics letters     Volume:  37     ISSN:  1539-4794     ISO Abbreviation:  Opt Lett     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-02     Completed Date:  2012-05-16     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  362-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipose Tissue / metabolism
Cell Line, Tumor
Microscopy, Fluorescence / methods*
Time Factors
Tomography, Optical Coherence / methods*
Grant Support
R01 CA120480/CA/NCI NIH HHS; R01 CA120480/CA/NCI NIH HHS; R01 CA153023/CA/NCI NIH HHS; R01 CA153023/CA/NCI NIH HHS; R01 EB007636/EB/NIBIB NIH HHS; R01 EB007636/EB/NIBIB NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Enhance the resolution of photonic crystal negative refraction imaging by metal grating.
Next Document:  Ultracompact polarization converter with a dual subwavelength trench built in a silicon-on-insulator...