| Integrated lymphography using fluorescence imaging and magnetic resonance imaging in intact mice. | |
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MedLine Citation:
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PMID: 21914429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed lymph drainage in living mice by an integrated imaging method using fluorescence imaging (FLI) and magnetic resonance imaging (MRI). Mice were subcutaneously injected with quantum dots and gadofluorine 8 into the right rear footpad. They were fixed on a transparent flat plate and underwent FLI and MRI successively. Small markers were attached to the mouse surface for spatial coregistration, and image fusion of FLIs and MRIs was performed. Two-dimensional fluorescence reflectance imaging was used for FLI. FLI and MRI provided generally consistent results and demonstrated lymphatic flow to the popliteal, sacral, and iliac lymph nodes in most mice and to the renal, inguinal, and lumbar-aortic lymph nodes in some mice. On the fusion images, the locations of the lymph nodes in the mouse trunk were in good agreement between FLI and MRI, indicating successful spatial registration even for the deep structures. The popliteal node tended to be visualized a little farther caudally in FLI than in MRI, presumably because the overlying tissues were thicker in the cranial portion. Integrated FLI/MRI lymphography with image fusion appears to be a useful tool for analysis of the murine lymphatic system. |
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Authors:
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Yusuke Inoue; Yoshitaka Masutani; Shigeru Kiryu; Tomoyuki Haishi; Kohki Yoshikawa; Makoto Watanabe; Morio Shimada; Kuni Ohtomo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular imaging Volume: 10 ISSN: 1536-0121 ISO Abbreviation: Mol Imaging Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-14 Completed Date: 2012-01-19 Revised Date: 2012-02-03 |
Medline Journal Info:
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Nlm Unique ID: 101120118 Medline TA: Mol Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 317-26 Citation Subset: IM |
Affiliation:
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Department of Radiology, Institure of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Japan. inoueys-tky@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media / administration & dosage, chemistry Female Fiducial Markers Gastrointestinal Contents Hindlimb Image Processing, Computer-Assisted Lymph Nodes / anatomy & histology, physiology, radiography* Lymphography / methods* Magnetic Resonance Imaging / methods* Mice Mice, Inbred BALB C Organometallic Compounds / administration & dosage, chemistry Quantum Dots Solanum tuberosum Spectrometry, Fluorescence / methods* Whole Body Imaging |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 0/gadofluorine 8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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