| Integrated fluorine-18 fluorodeoxyglucose (18F-FDG) PET/CT compared to standard contrast-enhanced CT for characterization and staging of pulmonary tumors eligible for surgical resection. | |
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MedLine Citation:
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PMID: 18651256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Accurate staging is necessary to determine the appropriate therapy in patients with lung cancer. Few studies have compared integrated fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and contrast-enhanced CT in the characterization and staging of pulmonary tumors considered eligible for surgical resection. PURPOSE: To compare 18F-FDG PET/CT with standard contrast-enhanced CT for the diagnosis and staging of lung neoplasms eligible for surgical resection. MATERIAL AND METHODS: Seventy-six consecutive patients (56 male, 20 female; mean age+/-SD, 63.4+/-20 years) with 84 pulmonary tumors suspected for malignancy and considered eligible for surgical resection were prospectively enrolled. Seventy-three malignant (65 non-small-cell lung carcinomas, one small-cell lung cancer, two carcinoids, and five metastases) and 11 benign lung tumors (three hamartomas, two sarcoidosis, one amyloidosis, one Wegener granulomatosis, one tuberculosis, and three areas of scarring) were finally diagnosed by histology. Tumor staging was based on the revised American Joint Committee on Cancer. RESULTS: In lesion characterization, the sensitivity and specificity of 18F-FDG PET/CT versus contrast-enhanced CT were 90% vs. 83% and 18% vs. 63% (P<0.05, McNemar test), respectively. In nodal staging, the sensitivity and specificity of 18F-FDG PET/CT versus contrast-enhanced CT were 78% vs. 46% and 80% vs. 93% (P<0.05), respectively. CONCLUSION: In patients with lung neoplasms considered eligible for surgical resection, (18)F-FDG PET/CT versus contrast-enhanced CT revealed higher sensitivity in nodal staging, but lower specificity both in lesion characterization and nodal staging. |
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Authors:
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E Quaia; G Tona; F Gelain; E Lubin; R Pizzolato; E Boscolo; L Bussoli |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 49 ISSN: 1600-0455 ISO Abbreviation: Acta Radiol Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-17 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: Sweden |
Other Details:
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Languages: eng Pagination: 995-1004 Citation Subset: IM |
Affiliation:
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Department of Radiology, Cattinara Hospital, University of Trieste, Trieste, Italy. equaia@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Contrast Media Female Fluorodeoxyglucose F18 / diagnostic use* Humans Image Enhancement Lung Diseases / diagnosis Lung Neoplasms / diagnosis*, surgery Male Middle Aged Neoplasm Staging / methods Positron-Emission Tomography* Prospective Studies Sensitivity and Specificity Tomography, X-Ray Computed* / methods |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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