| Integrated PET/CT for the evaluation of para-aortic nodal metastasis in locally advanced cervical cancer patients with negative conventional CT findings. | |
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MedLine Citation:
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PMID: 17945337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to evaluate the usefulness of integrated 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (PET/CT) for the detection of para-aortic nodal status and to test whether PET/CT change management strategy in locally advanced cervical cancer (LACC) patients with negative conventional CT findings. MATERIALS AND METHODS: Sixteen locally advanced (FIGO stage IIB-IVA) cervical squamous cancer patients with negative conventional CT findings were eligible to enter this prospective study. All patients underwent firstly PET/CT scans then extraperitoneal surgical exploration for para-aortic lymphadenectomy. Based on histopathologic confirmation, the accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the PET/CT for para-aortic lymph node metastasis were estimated. RESULTS: The median age was 48.7 (range 42-67). The accuracy, sensitivity, specificity, PPV and NPV of the PET/CT were 75%, 50%, 83.3%, 50% and 83.3%, respectively. The treatment was modified in four of sixteen (25%) patients; four patients received EFRT in combination with cisplatin chemotherapy instead of standard pelvic field radiotherapy in combination with cisplatin chemotherapy. CONCLUSION: Our results, despite our study group is small, suggest that PET/CT is an effective imaging technique in the evaluation of LACC with negative CT findings. It may help planning the management especially selecting radiation field. However, larger controlled studies are needed to recommend PET/CT as an alternative to pre-treatment surgical staging. |
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Authors:
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Y Yildirim; S Sehirali; M E Avci; C Yilmaz; K Ertopcu; S Tinar; Y Duman; S Sayhan |
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Publication Detail:
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Type: Journal Article Date: 2007-10-22 |
Journal Detail:
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Title: Gynecologic oncology Volume: 108 ISSN: 1095-6859 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-31 Completed Date: 2008-01-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 154-9 Citation Subset: IM |
Affiliation:
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Department of Gynecologic Oncology, Aegean Obstetrics and Gynecology Training and Research Hospital, Izmir, Turkey. dr.yusufyildirim@yahoo.com.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over CA-125 Antigen / blood Female Fluorodeoxyglucose F18 / diagnostic use* Humans Lymph Nodes / radionuclide imaging* Lymphatic Metastasis Middle Aged Neoplasm Recurrence, Local / blood, pathology, radionuclide imaging* Neoplasm Staging Positron-Emission Tomography Prospective Studies Radiopharmaceuticals / diagnostic use* Tomography, X-Ray Computed Uterine Cervical Neoplasms / blood, pathology, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/CA-125 Antigen; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
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