Document Detail

Integrated condition indices as a measure of whole effluent toxicity in zebrafish (Danio rerio).
MedLine Citation:
PMID:  11804066     Owner:  NLM     Status:  MEDLINE    
Toxic exposure of organisms interferes with organismal integrity at the biochemical level and ultimately gives rise to effects at the individual level. These effects may result in reductions in ecologically relevant characteristics such as growth, reproduction, and survival. A chronic toxicity test with zebrafish (Danio rerio) was conducted where fish were exposed to 50, 75, and 100% effluent for 28 d under flow-through conditions. Effects of effluent exposure were determined using endpoints of physiological (respiration during swimming), growth (condition, length, and weight), and reproductive (spawning and hatching) processes within the same population. Results clearly indicate that the condition and growth of zebrafish is depressed by exposure to the effluent. Also, increased oxygen consumption was found after 14, 21, and 28 d of exposure. Reproduction proved to correlate well with the condition of the motherfish in the control, and spawning and hatching were significantly depressed by effluent exposure. These results indicate that the evaluation of endpoints describing different ecologically relevant processes provides a rational assessment of the cause-effect relationships of effluent toxicity. This approach can quantify effects on different biological processes and can determine the interactions that occur between these different processes.
Roel Smolders; Lieven Bervoets; Boeck Gudrun De; Ronny Blust
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  21     ISSN:  0730-7268     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-23     Completed Date:  2002-04-23     Revised Date:  2006-04-19    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-93     Citation Subset:  IM    
Department of Biology, University of Antwerp (RUCA), Belgium.
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MeSH Terms
Body Weight / drug effects
Oxygen Consumption / drug effects
Reproduction / drug effects
Sewage / analysis*
Time Factors
Toxicity Tests
Waste Disposal, Fluid
Water Pollutants / toxicity*
Zebrafish / growth & development*
Reg. No./Substance:
0/Sewage; 0/Water Pollutants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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