Document Detail

Integrated backscatter analysis of carotid intima-media complex in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  18654734     Owner:  NLM     Status:  MEDLINE    
A number of studies based on conventional ultrasound scanning (CUS) gave contrasting results about the occurrence of early atherosclerosis in patients with systemic lupus erythematosus (SLE), while no study on early arterial sclerosis in the same patients are available. Recently, information on early arterial sclerosis can be provided by the integrated backscatter (IBS) analysis which reflects the collagen and calcium content within the vascular wall. In order to evaluate if atherosis and/or sclerosis of carotid arteries are early features of SLE, we performed carotid CUS and IBS analysis in 16 SLE patients (15 females; aged 37 +/- 10 years), free from clinically evident cardiovascular diseases and cardiovascular risk factors, with the only exception of five patients who had arterial hypertension. The same investigations were performed in 16 sex- and age-matched healthy control subjects. No statistically significant difference was observed either in carotid corrected IBS values or in carotid intima-media thickness (IMT) values between SLE patients and control subjects (-17.9 +/- 2.5 dB vs -19.0 +/- 1.7 dB, p = 0.14; 0.66 +/- 0.08 mm vs 0.62 +/- 0.13 mm, p = 0.35, respectively). The little sub-group of hypertensive SLE patients exhibited a significantly higher carotid corrected IBS mean value compared to control subjects (-16.4 +/- 3.1 dB vs -19.0 +/- 1.7 dB, p = 0.026), while it did not significantly differ in carotid IMT value from control group (0.67 +/- 0.09 mm vs 0.62 +/- 0.13 mm, respectively; p = 0.86). These findings show that neither atherosis nor sclerosis of carotid arteries are early features of SLE patients free from cardiovascular risk factors. Further studies are needed to clearly demonstrate that early carotid sclerosis affects hypertensive SLE patients.
Marco Rossi; Marta Mosca; Chiara Tani; Ferdinando Franzoni; Gino Santoro; Stefano Bombardieri
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Publication Detail:
Type:  Journal Article     Date:  2008-07-25
Journal Detail:
Title:  Clinical rheumatology     Volume:  27     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  1485-8     Citation Subset:  IM    
Department of Internal Medicine, University of Pisa, Pisa, Italy.
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MeSH Terms
Arteriosclerosis / ultrasonography*
Carotid Arteries / ultrasonography*
Case-Control Studies
Hypertension / complications,  ultrasonography*
Lupus Erythematosus, Systemic / complications,  ultrasonography*
Middle Aged
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Ultrasonography / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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