| Integrated PET/CT as a first-line re-staging modality in patients with suspected recurrence of ovarian cancer. | |
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MedLine Citation:
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PMID: 17180659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aims of this study were to compare CT with PET/CT results in patients with suspected ovarian cancer recurrence and to assess the impact of the PET/CT findings on their clinical management. METHODS: Thirty-two consecutive patients with suspected ovarian cancer recurrence were retrospectively included in the study. Abdominal contrast-enhanced CT and PET/CT with [(18)F]FDG, in addition to conventional follow-up, were performed in all 32 patients. After the comparison between CT and PET/CT results, based on clinical reports, changes in the clinical management of patients (intermodality changes) due to PET/CT information were analysed. RESULTS: Twenty of the 32 patients were positive at CT (62.5%) versus 29 (90.6%) at PET/CT. Intermodality changes in management, i.e. use of a different treatment modality, after PET/CT examination were indicated in 14/32 (44%) patients. In particular, before PET/CT study, the planned management was as follows: wait-and-see in 7/32 (22%), further instrumental examinations in 4/32 (12%), chemotherapy in 10/32 (31%), diagnostic surgical treatment in 6/32 (19%) and surgical treatment in the remaining 5/32 (16%). After PET/CT study, wait-and-see was indicated in 1/32 (3%), further instrumental examinations in 7/32 (22%), chemotherapy in 16/32 (50%), diagnostic surgical treatment in 2/32 (6%) and surgical treatment in the remaining 6/32 (19%). CONCLUSION: Integrated PET/CT could detect tumour relapse in a higher percentage of patients than could CT. A change in the clinical management was observed in 44% of cases when PET/CT information was added to conventional follow-up findings. |
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Authors:
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G Mangili; M Picchio; S Sironi; R Viganò; E Rabaiotti; D Bornaghi; V Bettinardi; C Crivellaro; C Messa; F Fazio |
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Publication Detail:
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Type: Journal Article Date: 2006-12-20 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 34 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-26 Completed Date: 2007-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 658-66 Citation Subset: IM |
Affiliation:
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Department of Gynaecology and Obstetrics, Scientific Institute San Raffaele, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Fluorodeoxyglucose F18 / diagnostic use Humans Middle Aged Neoplasm Recurrence, Local / diagnosis*, pathology Neoplasm Staging / methods Ovarian Neoplasms / diagnosis*, pathology*, radiography*, radionuclide imaging* Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Reproducibility of Results Retrospective Studies Tomography, X-Ray Computed / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
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