Document Detail

Integrated Raman- and angular-scattering microscopy.
MedLine Citation:
PMID:  18382527     Owner:  NLM     Status:  MEDLINE    
A microscopy system has been constructed that is capable of simultaneously acquiring both traditional Raman spectra as well as angle-resolved elastic-scattering patterns using a single focused laser spot less than 10 mum wide. The elastic-scattering signal was analyzed by generalized Lorenz-Mie theory, representing what we believe to be the first experimental validation of the theory's prediction of angular backscatter from single spheres. The microscope system exhibits 3 nm precision in predicting sphere diameters, while simultaneously yielding high-quality Raman signals. Applications to single cell analysis are envisioned.
Zachary J Smith; Andrew J Berger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Optics letters     Volume:  33     ISSN:  0146-9592     ISO Abbreviation:  Opt Lett     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-07-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  714-6     Citation Subset:  IM    
The Institute of Optics, University of Rochester, Rochester, NY 14627, USA.
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MeSH Terms
Equipment Design
Models, Theoretical
Optics and Photonics*
Polystyrenes / chemistry
Scattering, Radiation
Spectrum Analysis, Raman / instrumentation,  methods*
Grant Support
1-R21-DE016111-01A1/DE/NIDCR NIH HHS
Reg. No./Substance:

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