Document Detail


Integrated Raman- and angular-scattering microscopy.
MedLine Citation:
PMID:  18382527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A microscopy system has been constructed that is capable of simultaneously acquiring both traditional Raman spectra as well as angle-resolved elastic-scattering patterns using a single focused laser spot less than 10 mum wide. The elastic-scattering signal was analyzed by generalized Lorenz-Mie theory, representing what we believe to be the first experimental validation of the theory's prediction of angular backscatter from single spheres. The microscope system exhibits 3 nm precision in predicting sphere diameters, while simultaneously yielding high-quality Raman signals. Applications to single cell analysis are envisioned.
Authors:
Zachary J Smith; Andrew J Berger
Related Documents :
19551037 - Sers-based detection in an optofluidic ring resonator platform.
20935357 - Finding a needle in a chemical haystack: tip-enhanced raman scattering for studying car...
17014197 - Surface enhanced raman optical activity of molecules on orientationally averaged substr...
11148097 - More sub-doppler heterodyne frequency measurements on ocs between 56 and 63 thz.
22181417 - Yielding and structural relaxation in soft materials: evaluation of strain-rate frequen...
25429407 - A micro-fabricated force sensor using an all thin film piezoelectric active sensor.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Optics letters     Volume:  33     ISSN:  0146-9592     ISO Abbreviation:  Opt Lett     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-07-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  714-6     Citation Subset:  IM    
Affiliation:
The Institute of Optics, University of Rochester, Rochester, NY 14627, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Elasticity
Equipment Design
Lasers
Light
Microscopy
Models, Theoretical
Optics and Photonics*
Oscillometry
Polystyrenes / chemistry
Scattering, Radiation
Spectrum Analysis, Raman / instrumentation,  methods*
Grant Support
ID/Acronym/Agency:
1-R21-DE016111-01A1/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Polystyrenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of ...
Next Document:  Modal coupling in surface-corrugated long-period-grating fiber tapers.