| Integrated FDG PET-CT imaging improves staging in malignant pleural mesothelioma. | |
| | |
MedLine Citation:
|
PMID: 18084678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM of this study was to investigate, how often TNM staging is changed in patients with malignant pleural mesothelioma (MPM) by the application of integrated PET-CT compared to computed tomography alone and how often these changes are clinically relevant. PATIENTS, METHODS: We studied 17 patients (68 +/- 6 years, 8 women) with MPM. Integrated PET-CT scan and histological confirmation were performed in all patients. RESULTS: Final histological diagnosis confirmed 9 epithelial type, 2 sarcomatoid type and 6 biphasic type MPM. Mean standardized uptake value (SUV) was 5.9 +/- 1.9 in epithelial MPM and 15.1 +/- 10.2 in sarcomatoid MPM. CT and PET-CT revealed discordances in 8/17 (47%) patients in TNM classification with 4/8 (50%) being clinically relevant. PET-CT led to downstaging in 5 (29%) and upstaging in 3 (18%) patients. Mean survival time tended to be higher in the subgroup of patients with lower mean SUV. CONCLUSIONS: PET-CT seems to be a valuable tool in staging of MPM and leads to discordant findings in almost every second patient compared to CT alone. In many cases these differences are clinically relevant and have therapeutic consequences. |
| | |
Authors:
|
S Krüger; S Pauls; F M Mottaghy; A K Buck; H Schelzig; V Hombach; S N Reske |
Related Documents
:
|
20213798 - Positron emission tomography-computed tomography adds to the management of salivary gla... 20627648 - Vessel probe ct protocol in the study of esophageal carcinoma: can it improve preoperat... 19181468 - Integrated contrast-enhanced diagnostic whole-body pet/ct as a first-line restaging mod... 17059628 - Should fdg-pet scanning be routinely used for patients with an unknown head and neck sq... 22626458 - Can erosions on mri of the sacroiliac joints be reliably detected in patients with anky... 10726068 - Aspects of imaging in the assessment and follow up of benign prostatic hyperplasia. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nuklearmedizin. Nuclear medicine Volume: 46 ISSN: 0029-5566 ISO Abbreviation: Nuklearmedizin Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-12-17 Completed Date: 2008-03-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7609387 Medline TA: Nuklearmedizin Country: Germany |
Other Details:
|
Languages: eng Pagination: 239-43 Citation Subset: IM |
Affiliation:
|
Medizinische Klinik I, Universitätsklinikum Aachen, Pauwelstrasse 30, 52057 Aachen, Germany. stkrueger@ukaachen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Mesothelioma / pathology, radiography*, radionuclide imaging* Middle Aged Neoplasm Staging / methods* Pleural Neoplasms / pathology, radiography*, radionuclide imaging* Radiography, Thoracic Radiopharmaceuticals / diagnostic use* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
|
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Specific accumulation of 18F-deoxyglucose in three-dimensional long-term cultures of human and roden...
Next Document: Sentinel lymph node involvement and a high Breslow index are independent factors of risk for early r...