Document Detail

Integral photoradiation therapy of multifocal bladder tumors.
MedLine Citation:
PMID:  2945725     Owner:  NLM     Status:  MEDLINE    
Focal and diffuse hematoporphyrin derivative (HpD) photodynamic therapy was used for the treatment of resistant transitional cell carcinoma in situ (Tis) in 30 patients. Patients were given HpD intravenously followed by either focal light irradiation (630 nm) or diffuse bladder irradiation via a light bulb fiber. The light source was an argon ion pumped dye laser circulating rhodamine B dye. All patients were followed with periodic cystoscopic examinations, bladder biopsies, and urine cytologic examinations. All of the 15 patients who underwent focal therapy had biopsy and cytologic evidence of disappearance of the lesion in the treated area at the 3-month follow-up cystoscopic examination. Eight patients have experienced one or more recurrent lesions either in the treated area or in distant areas, and in each the recurrence was successfully treated with HpD photodynamic therapy. Eight of the 11 patients with diffuse Tis have returned for their 3-month follow-up evaluation, and all demonstrated disappearance of tumor (3 of these 8 patients have subsequently developed focal recurrent Tis). Four patients had diffuse Tis plus Ta lesions (2 patients) or T2 lesions (2 patients), and all had disappearance of the Tis, but persistence of the Ta or T2 disease. We conclude that HpD photodynamic therapy appears effective in the treatment of resistant Tis.
R C Benson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European urology     Volume:  12 Suppl 1     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-12-09     Completed Date:  1986-12-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Transitional Cell / surgery,  therapy
Hematoporphyrin Derivative
Hematoporphyrins / therapeutic use*
Laser Therapy
Middle Aged
Urinary Bladder Neoplasms / surgery,  therapy*
Reg. No./Substance:
0/Hematoporphyrins; 68335-15-9/Hematoporphyrin Derivative

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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