Document Detail


Intake of umami-tasting solutions by mice: a genetic analysis.
MedLine Citation:
PMID:  10736356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In two-bottle preference tests with water and solutions of monosodium glutamate (MSG) and inosine-5'-monophosphate (IMP), mice from the C57BL/6ByJ inbred strain consumed more and had higher preferences for these solutions compared with mice from the 129/J strain. The C57BL/6ByJ mice consumed 300 mmol/L MSG in large amounts, which were comparable to intakes of highly preferred solutions of sweeteners. The strain differences in voluntary consumption of 300 mmol/L MSG depended at least in part on postingestive effects because prior experience with MSG influenced the expression of the strain difference in MSG acceptance. The strain difference in MSG acceptance was in the opposite direction to the strain difference in NaCl acceptance and was not affected by previous consumption of saccharin. Although the C57BL/6ByJ mice had higher avidity for both MSG and sweeteners than did the 129/J mice, there was no correlation between preferences for these solutions in the second hybrid generation (F(2)) derived from these two strains. Thus, the strain differences in MSG acceptance are not related to the strain differences in salty or sweet taste responsiveness and most likely represent specific umami taste responsiveness. High acceptance of MSG solutions by the C57BL/6ByJ mice was inherited as a recessive trait in the F(2) generation. Further genetic linkage analyses using the F(2) hybrids are being conducted to map chromosomal locations of genes determining the strain difference in MSG acceptance.
Authors:
A A Bachmanov; M G Tordoff; G K Beauchamp
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  130     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-25     Completed Date:  2000-04-25     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  935S-41S     Citation Subset:  IM    
Affiliation:
Monell Chemical Senses Center, Philadelphia, PA 19104-3308, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drinking / drug effects*
Female
Food Additives / pharmacology*
Food Preferences / physiology
Genes, Recessive / physiology
Hybridization, Genetic
Male
Mice / genetics,  physiology*
Mice, Inbred C57BL
Mice, Inbred Strains
Saccharin / pharmacology
Sodium Chloride / pharmacology
Sodium Glutamate / pharmacology*
Solutions
Species Specificity
Sweetening Agents / pharmacology
Taste / drug effects*
Grant Support
ID/Acronym/Agency:
DC 00882/DC/NIDCD NIH HHS; R01 DC000882/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Food Additives; 0/Solutions; 0/Sweetening Agents; 142-47-2/Sodium Glutamate; 7647-14-5/Sodium Chloride; 81-07-2/Saccharin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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