Document Detail

Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain.
MedLine Citation:
PMID:  10334645     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the relationship between gastric cancer and the intake of specific carotenoids (alpha-carotene, beta-carotene, lutein, and lycopene) and flavonoids (quercetin, kaempferol, myricetin, and luteolin) using new data on their concentration in foods. METHODS: Case-control study carried out in Spain that included 354 cases of gastric cancer and 354 controls, matched by age, gender, area of residence and hospital. Usual food intake was assessed using a dietary history questionnaire. RESULTS: In a multivariate model adjusted for several dietary factors, no association was found between intake of any of the studied carotenoids and the risk of gastric cancer. The adjusted OR of gastric cancer for the highest quartile of total flavonoid intake versus the lowest quartile was 0.44 (95 percent confidence interval [CI] = 0.25-0.78; P for trend = 0.003). Kaempferol intake was found to be protective (OR = 0.48; CI = 0.26-0.88; P for trend = 0.04) comparing the highest versus the lowest quartile of intake. A trend toward lower risk of stomach cancer with higher intake of quercetin was also found. CONCLUSIONS: The results of this study support the hypothesis that the well-established protective effect of fruit and vegetables against gastric cancer could, in part, be due to the presence of flavonoids.
R Garcia-Closas; C A Gonzalez; A Agudo; E Riboli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  10     ISSN:  0957-5243     ISO Abbreviation:  Cancer Causes Control     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-07-06     Completed Date:  1999-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
Research Unit of the University Hospital of Canarias, Tenerife, Spain.
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MeSH Terms
Aged, 80 and over
Carotenoids / pharmacology*
Case-Control Studies
Flavonoids / pharmacology*
Middle Aged
Risk Assessment
Spain / epidemiology
Stomach Neoplasms / epidemiology,  etiology*,  prevention & control
Reg. No./Substance:
0/Flavonoids; 36-88-4/Carotenoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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