Document Detail


Intake of omega-3 and omega-6 fatty acids and risk of ovarian cancer.
MedLine Citation:
PMID:  22933054     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Limited experimental evidence suggests that omega-3 polyunsaturated (n-3) fatty acids inhibit the proliferation of ovarian cancer cells in vitro, whereas omega-6 polyunsaturated (n-6) fatty acids have been shown to promote carcinogenesis, but epidemiological studies to date have been inconclusive. Our aim was to evaluate the role of polyunsaturated fatty acids in ovarian carcinogenesis. METHODS: Participants in the Australian Ovarian Cancer Study (1,366 cases and 1,414 population controls) self-completed risk factor and food frequency questionnaires. Logistic regression models were used to calculate adjusted odds ratio (OR) and 95 % confidence intervals (CI). RESULTS: We found no association between intake of total n-3 fatty acids from foods, or the individual n-3 fatty acids-alpha-linolenic, eicosapentaenoic, docosapentaenoic, docosahexaenoic acids-and ovarian cancer risk. High intake of total n-6 fatty acids was inversely associated with risk (OR for highest vs. lowest category 0.78, 95 % CI 0.60-1.00, p-trend 0.04); however, the association was restricted to n-6 fatty acids from avocado, vegetables, and nuts. Neither higher intake of the individual n-6 fatty acids nor the ratio of n-3 to n-6 fatty acids was associated with ovarian cancer risk. We found no evidence that risk varied by supplement use. CONCLUSIONS: Our data provide no evidence of a protective role for n-3 fatty acids in ovarian carcinogenesis. The benefit, if any, of higher intake of n-6 fatty acids is due to general properties of the food sources, rather than due to the n-6 fatty acids per se.
Authors:
T I Ibiebele; C M Nagle; C J Bain; P M Webb
Related Documents :
3096014 - Essential fatty acid patterns in preeclampsia.
11224654 - Directed modification instead of normalization of fatty acid patterns in cystic fibrosi...
12768444 - Two cases of glucose-6-phosphate dehydrogenase-deficient nepalese belonging to the g6pd...
7990664 - Serum fatty acid profiles in cystic fibrosis patients and their parents.
20097564 - N-heterocyclic derived m1 positive allosteric modulators.
3056524 - The lactose carrier of klebsiella pneumoniae m5a1; the physiology of transport and the ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-30
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  -     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Genetics and Population Health Division, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, QLD, 4006, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of metal surface characteristics on the adhesion performance of the integrated low-level ener...
Next Document:  Virtual Selves, Real Relationships: An Exploration of the Context and Role for Social Interactions i...