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Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma: A meta-analysis of observational studies.
MedLine Citation:
PMID:  23319052     Owner:  NLM     Status:  Publisher    
Quantification of the association between the intake of fruit and vegetables and risk of esophageal squamous cell carcinoma (ESCC) is controversial even though several studies have explored this association. We summarized the evidence from observational studies in categorical, linear, and non-linear dose-response meta-analyses. Eligible studies published up to 31 July 2012 were retrieved via computer searches of MEDLINE and EMBASE as well as manual review of references. Random-effects models were used to calculate summary relative risks (SRRs) and the corresponding 95% confidence intervals (CIs). A total of 32 studies involving 10,037 cases of ESCC were included in this meta-analysis. The SRRs for the highest vs. lowest intake were 0.56 (95% confidence interval (CI), 0.45-0.69) for vegetable intake and 0.53 (95% CI, 0.44-0.64) for fruit intake (P(heterogeneity) <0.001 for both). Similar results were observed in a linear dose-response analysis. There was evidence of non-linear associations for intakes of fruit (P(non-linearity) <0.001) and vegetables (P(nonlinearity) =0.041). There was no evidence of publication bias. These data support the hypothesis that intakes of vegetables and fruit may significantly reduce the risk of ESCC. Further investigation with prospective designs, validated questionnaires, and good control of important confounders is warranted. © 2013 Wiley Periodicals, Inc.
Jun Liu; Jian Wang; Ye Leng; Changxing Lv
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 UICC.
Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, China.
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