Document Detail


Intake fraction for multimedia pollutants: a tool for life cycle analysis and comparative risk assessment.
MedLine Citation:
PMID:  12442988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We employ the intake fraction (iF) as an effective tool for expressing the source-to-intake relationship for pollutant emissions in life cycle analysis (LCA) or comparative risk assessment. Intake fraction is the fraction of chemical mass emitted into the environment that eventually passes into a member of the population through inhalation, ingestion, or dermal exposure. To date, this concept has been primarily applied to pollutants whose primary route of exposure is inhalation. Here we extend the use of iF to multimedia pollutants with multiple exposure pathways. We use a level III multimedia model to calculate iF for TCDD and compare the result to one calculated from measured levels of dioxin toxic equivalents in the environment. We calculate iF for emissions to air and surface water for 308 chemicals. We correlate the primary exposure route with the magnitudes of the octanol-water partition coefficient, Kow, and of the air-water partitioning coefficient (dimensionless Henry constant), Kaw. This results in value ranges of Kow and Kaw where the chemical exposure route can be classified with limited input data requirements as primarily inhalation, primarily ingestion, or multipathway. For the inhalation and ingestion dominant pollutants, we also define empirical relationships based on chemical properties for quantifying the intake fraction. The empirical relationships facilitate rapid evaluation of many chemicals in terms of the intake. By defining a theoretical upper limit for iF in a multimedia environment we find that iF calculations provide insight into the multimedia model algorithms and help identify unusual patterns of exposure and questionable exposure model results.
Authors:
Deborah H Bennett; Manuele D Margni; Thomas E McKone; Olivier Jolliet
Related Documents :
3232688 - Validity and reliability of a method for retrospective evaluation of chlorophenate expo...
6838668 - Chronic exposure of rabbits to 0.5 and 5 mw/cm2 2450-mhz cw microwave radiation.
9515068 - Dietary exposure to chemical contaminants from traditional food among adult dene/métis...
848428 - A study of benzene exposure versus urinary phenol levels.
21740528 - Foetal exposure to food and environmental carcinogens in humans.
20085278 - Evaluation of a real-time polymerase chain reaction (pcr) assay for detection of anisak...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Risk analysis : an official publication of the Society for Risk Analysis     Volume:  22     ISSN:  0272-4332     ISO Abbreviation:  Risk Anal.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-21     Completed Date:  2002-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109978     Medline TA:  Risk Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  905-18     Citation Subset:  IM    
Affiliation:
School of Public Health, Harvard University, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Algorithms
Environment*
Environmental Exposure
Environmental Pollutants / administration & dosage,  toxicity
Humans
Life Tables
Models, Theoretical
Risk Assessment / methods*,  statistics & numerical data
United States
Chemical
Reg. No./Substance:
0/Environmental Pollutants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A regression-based approach for estimating primary and secondary particulate matter intake fractions...
Next Document:  Life cycle emission distributions within the economy: implications for life cycle impact assessment.