| Intake of ethanol and reinforcing fluids in rats bred for susceptibility to stress. | |
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MedLine Citation:
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PMID: 16762688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats have been selectively bred in our laboratory based on how swim-test behavior is affected by stress. Following exposure to an acute stressor, active swim-test behavior is reduced in the swim-test susceptible (SUS) line but is not reduced in the swim-test resistant (RES) line. Earlier findings indicate that SUS rats have reduced central serotonin and dopamine levels relative to normal, random-bred (i.e., nonselected [NS]) rats and RES rats, suggesting that SUS rats might respond differently to reinforcing substances, particularly ethanol. We report here comparison of SUS, NS, and RES rats regarding consumption of ethanol. Also examined was consumption of saccharin, sucrose, and quinine. Testing involved a two-bottle, free-choice method of measuring intake of substances in a home cage. Intake of each substance was tested across a range of concentrations. The results indicate that the SUS rats, tested across 14 generations, consume markedly more ethanol than the other two lines; in fact, SUS rats consume amounts similar to that ingested by lines/strains of rats bred specifically for ethanol intake. Similar to other alcohol-preferring rats, SUS rats show an increased affinity for saccharin solutions and a marked increase in their total daily fluid intake when a sweet-tasting saccharin or sucrose solution is available. These results indicate that a propensity to drink alcohol occurs in a line of rats that were selectively bred, not for alcohol intake, but for vulnerability to stress. |
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Authors:
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Charles H K West; Jay M Weiss |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 38 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-06-09 Completed Date: 2006-08-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: United States |
Other Details:
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Languages: eng Pagination: 13-27 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. cwest@emory.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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psychology* Animals Breeding Disease Susceptibility Drinking Female Male Quinine / administration & dosage Rats Reinforcement (Psychology)* Saccharin / administration & dosage Stress, Physiological / psychology* Sucrose / administration & dosage Swimming |
| Chemical | |
Reg. No./Substance:
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130-95-0/Quinine; 57-50-1/Sucrose; 81-07-2/Saccharin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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