Document Detail

Intake of omega-3 and omega-6 fatty acids and risk of basal and squamous cell carcinomas of the skin: a longitudinal community-based study in Australian adults.
MedLine Citation:
PMID:  22974045     Owner:  NLM     Status:  MEDLINE    
Intake of omega-3 and omega-6 fatty acids may modify the risk of basal and squamous cell carcinoma of the skin (BCC and SCC), but population-based evidence is limited and inconsistent. We examined prospectively associations between intake of omega-3 and omega-6 fatty acids estimated from food frequency questionnaires and BCC and SCC incidence among 1322 randomly selected adults in Nambour, Australia. Relative risks (RR) and 95% confidence intervals (CI) were estimated based on histologically confirmed tumors diagnosed between 1997 and 2007. Incidence of BCC was lowest in the middle third of both total omega-6 intake (RR(mv.adj) = 0.74, 95% CI = 0.56-0.97) and linoleic acid intake (RR(mv.adj) = 0.75, 95% CI = 0.57-0.99) compared with the lowest third of intake. Evidence for associations with SCC was weak, though persons with arachidonic acid intake in the middle third had a marginally increased risk of SCC (RR(mv.adj) = 1.42, 95% CI = 1.00-2.02). Consumption of omega-3 fatty acids was not associated with subsequent skin cancer risk. Suggestion that intake of arachidonic acid may be associated with increased SCC incidence and total omega-6 with reduced BCC from our study is still highly uncertain and may be due to chance. These data do not support an association between these fatty acids and risk of BCC or SCC.
Sarah C Wallingford; Josephina A van As; Maria Celia Hughes; Torukiri I Ibiebele; Adèle C Green; Jolieke C van der Pols
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-13
Journal Detail:
Title:  Nutrition and cancer     Volume:  64     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-03-27     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  982-90     Citation Subset:  IM    
Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Australia.
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MeSH Terms
Australia / epidemiology
Carcinoma, Basal Cell / epidemiology*,  prevention & control
Carcinoma, Squamous Cell / epidemiology*,  prevention & control
Confidence Intervals
Energy Intake
Fatty Acids, Omega-3 / administration & dosage*
Fatty Acids, Omega-6 / administration & dosage*
Longitudinal Studies
Middle Aged
Multivariate Analysis
Prospective Studies
Risk Factors
Skin Neoplasms / epidemiology*,  prevention & control
Treatment Outcome
Grant Support
89912//Medical Research Council; G0802468//Medical Research Council; G0802468(89912)//Medical Research Council
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6

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