Document Detail

Intact implicit verbal relational memory in medial temporal lobe amnesia.
MedLine Citation:
PMID:  22609574     Owner:  NLM     Status:  MEDLINE    
To elucidate the role of the hippocampus in unaware relational memory, the present study examined the performance of amnesic patients with medial temporal lobe (MTL) lesions on a cued category-exemplar generation task. In contrast to a prior study in which amnesic patients showed impaired performance (Verfaellie et al., Cognitive, Affective, and Behavioral Neuroscience, 2006, 6, 91-101), the current study employed a task that required active processing of the context word at test. In this version of the task, amnesic patients, like control participants, showed enhanced category exemplar priming when the context word associated with the target at study was reinstated at test. The finding of intact implicit memory for novel associations following hippocampal lesions in a task that requires flexible use of retrieval cues is inconsistent with a relational memory view that suggests that the hippocampus is critical for all forms of relational memory, regardless of awareness. Instead, it suggests that unaware memory for within-domain associations does not require MTL mediation.
Mieke Verfaelllie; Karen F LaRocque; Margaret M Keane
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-05-17
Journal Detail:
Title:  Neuropsychologia     Volume:  50     ISSN:  1873-3514     ISO Abbreviation:  Neuropsychologia     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-11-29     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0020713     Medline TA:  Neuropsychologia     Country:  England    
Other Details:
Languages:  eng     Pagination:  2100-6     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, USA.
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MeSH Terms
Aged, 80 and over
Amnesia / pathology,  physiopathology*
Case-Control Studies
Concept Formation*
Hippocampus / pathology,  physiopathology*
Mental Recall*
Middle Aged
Neuropsychological Tests
Organ Size
Repetition Priming*
Temporal Lobe / pathology,  physiopathology*
Grant Support
57681//PHS HHS; R01 MH057681/MH/NIMH NIH HHS

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