Document Detail


Insulitis in type 2 diabetes.
MedLine Citation:
PMID:  18834448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Islets of patients with type 2 diabetes have the feature of an inflammatory process reflected by the presence of cytokines, immune cells, beta-cell apoptosis, amyloid deposits and fibrosis. Indeed, beta-cells from patients with type 2 diabetes display inflammatory markers, including increased interleukin (IL)-1 beta expression. Furthermore, increased islet-associated macrophages are observed in human type 2 diabetic patients and in most animal models of diabetes. Importantly, increased numbers of macrophages are detectable very early in high fat-fed mice islets, before the onset of diabetes. These immune cells are most likely attracted by islet-derived chemokines, produced in response to metabolic stress, and under the control of IL-1 beta. It follows that modulation of intra-islet inflammatory mediators, in particular IL-1 beta, may prevent insulitis in type 2 diabetes and therefore presents itself as a possible causal therapy with disease-modifying potential.
Authors:
M Böni-Schnetzler; J A Ehses; M Faulenbach; M Y Donath
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  10 Suppl 4     ISSN:  1463-1326     ISO Abbreviation:  Diabetes Obes Metab     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2008-12-09     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-4     Citation Subset:  IM    
Affiliation:
Clinic of Endocrinology and Diabetes and Centre for Integrated Human Physiology, University Hospital of Zurich, Zurich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / physiology
Diabetes Mellitus, Type 2 / immunology*,  metabolism
Female
Glucagon / biosynthesis
Humans
Immunohistochemistry
Insulin / biosynthesis,  immunology*
Interleukin-1beta / immunology*,  metabolism
Islets of Langerhans / immunology*,  metabolism
Male
Mice
Rats
Chemical
Reg. No./Substance:
0/Interleukin-1beta; 11061-68-0/Insulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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