| Insulinoma--clinical experience in ten cases. | |
| | |
MedLine Citation:
|
PMID: 8205495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During the period between January 1981 and December 1992, a total of ten patients with pathologically confirmed insulinoma were studied. All patients presented with variable degrees of neuroglycopenic symptoms and Whipple's triad. The ratio of insulin to glucose after an overnight fast was greater than 0.3 in 90% (9/10) of patients. Eight patients who received supervised fasting developed neuroglycopenia with relative hyperinsulinemia within 48 hours of fasting. Four of 8 patients developed hypoglycemia during a 5-hour oral glucose tolerance test (OGTT). Calcium infusion test was more sensitive in patients with an initially higher plasma glucose. The detection rates of various localization studies were 12.5% (1/8) by abdominal ultrasonography, 37.5% (3/8) by abdominal CT scan, 50% (5/10) by selective superior mesenteric and celiac arteriography. Transhepatic portal venous sampling (THPVS) detected insulinomas in 4 of 4 cases. Endoscopic ultrasonography and intraoperative ultrasonography were performed on 1 and 2 cases respectively, and were able to localize the lesions successfully. All patients received surgical treatment including enucleation (n = 2), subtotal pancreatectomy (n = 3) and distal pancreatectomy (n = 5). All patients had single tumors which were all benign islet cell adenomas. The mean size of the tumors was 15.5 +/- 2.0 mm in diameter (range: 8 to 30 mm) and mainly located in the body (50%) and tail (40%), only 1 in the pancreatic head. All symptoms of hypoglycemia subsided after operation. Hyperglycemia was observed in all patients immediately after operation, and most of them resumed normoglycemia within 8 days. However, the 2 patients who had impaired OGTT preoperatively had persistent hyperglycemia after operation and therefore were diagnosed as having diabetes (NIDDM). |
| | |
Authors:
|
H Y Chang; H S Huang; J D Lin; B Y Huang; M J Huang; L B Jeng |
Related Documents
:
|
17589075 - Severe hyponatremia - is rapid correction safe? 10382785 - Interleukin 1 receptor antagonist and e-selectin concentrations: a comparison in patien... 6712475 - The spectrum of biliary tract obstruction from chronic pancreatitis. 4053345 - Effect of secretin upon the levels of pancreatic enzymes in blood serum. 21051895 - Can high-sensitivity c-reactive protein and plasma homocysteine levels independently pr... 2424425 - The proteinase inhibitor complexes (antithrombin iii-thrombin, alpha 2antiplasmin-plasm... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital Volume: 17 ISSN: - ISO Abbreviation: Changgeng Yi Xue Za Zhi Publication Date: 1994 Mar |
Date Detail:
|
Created Date: 1994-07-12 Completed Date: 1994-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9809559 Medline TA: Changgeng Yi Xue Za Zhi Country: TAIWAN |
Other Details:
|
Languages: eng Pagination: 28-38 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Glucose / analysis Female Follow-Up Studies Humans Insulin / blood Insulinoma / diagnosis*, metabolism, therapy Male Middle Aged Pancreatic Neoplasms / diagnosis*, metabolism, therapy |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preference for the Diskhaler rather than the metered dose inhaler in patients with airway obstructio...
Next Document: Traumatic patellar tendon ruptures--a follow-up study of primary repair and neutralization wire.