Document Detail

Insulinoma associated with pregnancy.
MedLine Citation:
PMID:  17980876     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report three cases of insulinoma associated with pregnancy. DESIGN: Case report. SETTING: Divisions of Endocrinology and Gastroenterologic Surgery, Hospital de Clínicas, University of Buenos Aires, Argentina. PATIENT(S): Three patients with hypoglycemic signs due to insulinoma appearing during pregnancy or shortly after delivery. INTERVENTION(S): Laparoscopic excision of insulinoma in two and laparotomy in one of the patients were performed after the end of their pregnancies. MAIN OUTCOME MEASURE(S): Disappearance of hypoglycemic crises and histologic proof of insulinomas. RESULT(S): In two of the three patients, hypoglycemia occurred within 2-12 weeks after delivery, suggesting that signs could have been masked because of metabolic changes during gestation; in the third patient, hypoglycemia appeared in the first trimester but was misinterpreted. CONCLUSION(S): Insulinoma is often not suspected during the first trimester of pregnancy because signs resemble episodes of hypotension or emesis. Later, with the increase in insulin resistance, symptoms subside.
Adriana G Diaz; Javier Herrera; Mariana López; Félix M Puchulu; Pedro Ferraina; Oscar D Bruno
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-11-05
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-01     Completed Date:  2008-07-17     Revised Date:  2009-02-20    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199.e1-4     Citation Subset:  IM    
Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
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MeSH Terms
Diagnostic Errors
Hypoglycemia / etiology*,  surgery
Insulinoma / complications,  diagnosis*,  surgery
Pancreatic Neoplasms / complications,  diagnosis*,  surgery
Postpartum Period
Pregnancy Complications, Neoplastic / diagnosis*,  surgery
Pregnancy Trimester, First
Treatment Outcome
Comment In:
Fertil Steril. 2009 Feb;91(2):656   [PMID:  19111295 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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