Document Detail

Insulinoma: Diagnosis and surgical treatment. Retrospective analysis of 31 cases.
MedLine Citation:
PMID:  17090842     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Insulinomas are rare tumors that are usually benign, single and curable by simple surgical excision. They can present problems in diagnosis and localization. STUDY DESIGN: Retrospective analysis of patients with insulinoma managed during a 13-year period (1992-2005) at a tertiary-level institution. RESULTS: 31 patients (mean age 38.4 [SD 13.3] years; 16 men) presented with hypoglycemic symptoms for 4.6 (5.5) years. In 22 (71%) patients, the lesion was successfully localized pre-operatively. Of various pre-operative localization techniques, CT angiography (5/6; 83%), intra-arterial digital subtraction angiography (11/17; 65%), dual-phase CT (8/14; 57%) and conventional MRI (4/13; 31%) had high rates of successful tumor localization. Intra-operative palpation and ultrasonography also had localization success rates (22/30 [76%] and 11/12 [92%], respectively); each identified one lesion that the other procedure did not localize. Of the 30 patients who underwent surgery, 28 had solitary tumor. CONCLUSION: Pre-operative investigations to localize insulinoma are helpful despite the availability of intra-operative ultrasound. Dual-phase CT should be the non-invasive investigation of first choice.
Viveka P Jyotsna; Neil Rangel; Sujoy Pal; Ashu Seith; Peush Sahni; A C Ammini
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  25     ISSN:  0254-8860     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-11-08     Completed Date:  2006-12-21     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  IM    
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi 110 029, India.
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MeSH Terms
Insulinoma / diagnosis*,  surgery*
Magnetic Resonance Imaging
Middle Aged
Pancreatic Neoplasms / diagnosis*,  surgery*
Postoperative Complications
Retrospective Studies
Tomography, X-Ray Computed
Treatment Outcome
Comment In:
Indian J Gastroenterol. 2007 Jan-Feb;26(1):50-1; author reply 51   [PMID:  17401249 ]

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