| Insulinoma: Diagnosis and surgical treatment. Retrospective analysis of 31 cases. | |
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MedLine Citation:
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PMID: 17090842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Insulinomas are rare tumors that are usually benign, single and curable by simple surgical excision. They can present problems in diagnosis and localization. STUDY DESIGN: Retrospective analysis of patients with insulinoma managed during a 13-year period (1992-2005) at a tertiary-level institution. RESULTS: 31 patients (mean age 38.4 [SD 13.3] years; 16 men) presented with hypoglycemic symptoms for 4.6 (5.5) years. In 22 (71%) patients, the lesion was successfully localized pre-operatively. Of various pre-operative localization techniques, CT angiography (5/6; 83%), intra-arterial digital subtraction angiography (11/17; 65%), dual-phase CT (8/14; 57%) and conventional MRI (4/13; 31%) had high rates of successful tumor localization. Intra-operative palpation and ultrasonography also had localization success rates (22/30 [76%] and 11/12 [92%], respectively); each identified one lesion that the other procedure did not localize. Of the 30 patients who underwent surgery, 28 had solitary tumor. CONCLUSION: Pre-operative investigations to localize insulinoma are helpful despite the availability of intra-operative ultrasound. Dual-phase CT should be the non-invasive investigation of first choice. |
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Authors:
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Viveka P Jyotsna; Neil Rangel; Sujoy Pal; Ashu Seith; Peush Sahni; A C Ammini |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology Volume: 25 ISSN: 0254-8860 ISO Abbreviation: Indian J Gastroenterol Publication Date: 2006 Sep-Oct |
Date Detail:
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Created Date: 2006-11-08 Completed Date: 2006-12-21 Revised Date: 2010-03-23 |
Medline Journal Info:
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Nlm Unique ID: 8409436 Medline TA: Indian J Gastroenterol Country: India |
Other Details:
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Languages: eng Pagination: 244-7 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi 110 029, India. vivekapjyotsna@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Humans Insulinoma / diagnosis*, surgery* Magnetic Resonance Imaging Male Middle Aged Pancreatectomy Pancreatic Neoplasms / diagnosis*, surgery* Postoperative Complications Retrospective Studies Tomography, X-Ray Computed Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Indian J Gastroenterol. 2007 Jan-Feb;26(1):50-1; author reply 51
[PMID:
17401249
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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