Document Detail


Insulin suppressive effects of aminotetralin analogs and of dopamine.
MedLine Citation:
PMID:  6391938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study concerned the effects of 2-amino-6,7-(OH)2-1,2,3, 4-tetrahydronaphthalene (A-6,7-DTN), dipropyl-A-6,7-DTN and dopamine on plasma levels of immunoreactive insulin (IRI) in cattle. During infusions of A-6,7-DTN, dipropyl-A-6,7-DTN and dopamine, the circulating levels of IRI decreased. In response to A-6,7-DTN, the levels of glucose increased whereas non-esterified fatty acids did not change. The decrease of IRI during additional infusions of A-6,7-DTN was not modified by prolonged administration of A-6,7-DTN. During infusions of A-6,7-DTN there was no increase in response to the administration of glucose and tolbutamide. However, if the beta-adrenergic agonist isoproterenol was infused, IRI increased in the presence of A-6,7-DTN. During, infusions of the alpha-adrenergic blocking agent, phentolamine, levels of IRI increased within minutes while glucose did not change. Concomitant infusions of A-6,7-DTN and phentolamine caused IRI to decrease and the rise in glucose levels seen in the absence of phentolamine was inhibited. In conclusion, enhanced dopaminergic activity inhibited IRI secretion. The suppressive effects of A-6,7-DTN were due primarily to its dopaminergic properties, but A-6,7-DTN also possessed some characteristics of an alpha-adrenergic agonist. beta-Adrenergic stimulation reversed the suppressive effects of A-6,7-DTN on IRI secretion.
Authors:
J W Blum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  105     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-02-04     Completed Date:  1985-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Dopamine / pharmacology*
Insulin / blood,  secretion
Insulin Antagonists*
Isoproterenol / pharmacology
Male
Naphthalenes / pharmacology*
Phentolamine / pharmacology
Sodium Chloride / pharmacology
Tetrahydronaphthalenes / pharmacology*
Tolbutamide / pharmacology
Chemical
Reg. No./Substance:
0/Insulin Antagonists; 0/Naphthalenes; 0/Tetrahydronaphthalenes; 11061-68-0/Insulin; 50-60-2/Phentolamine; 53463-78-8/ADTN; 64-77-7/Tolbutamide; 66185-60-2/2-(N,N-dipropyl)amino-6,7-dihydroxytetralin; 7647-14-5/Sodium Chloride; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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