Document Detail

Insulin-stimulated increase in serum leptin levels precedes and correlates with weight gain during insulin therapy in type 2 diabetes.
MedLine Citation:
PMID:  19509109     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Infusion of insulin acutely stimulates leptin production and chronic insulin treatment is associated with elevated serum leptin levels and body weight in subjects with type 2 diabetes. OBJECTIVE: The objective of the study was to investigate the relationship between insulin administration, leptin levels, and weight gain in subjects with type 2 diabetes. DESIGN: This was a post hoc analysis of two randomized, controlled trials. SETTING: The study was conducted at an outpatient clinic. SUBJECTS: Subjects included 35 (study 1) and 32 (study 2) poorly controlled oral hypoglycemic agent (OHA)-treated type 2 diabetic subjects. INTERVENTION: Study 1: subjects were investigated during a hyperinsulinemic, euglycemic glucose clamp and 12 months after being randomly allocated to start insulin or continue on OHAs. Study 2: 1 yr treatment with either OHAs and lifestyle intervention or insulin with or without concomitant lifestyle intervention. MAIN OUTCOME MEASURE: Changes in serum leptin levels during clamp and during 1 yr of treatment in relationship to changes in body weight. RESULTS: Study 1: during acute insulin infusion leptin levels increased by 10% (P < 0.001). During 1 yr of insulin therapy, mean body weight increased by 6%, whereas the fasting leptin levels increased by 108% (both P < 0.001). The weight gain observed at 1 yr correlated with the increase in leptin levels observed during the clamp (r = 0.62, P = 0.003). Study 2: mean body weight increased by 4% (P < 0.01), whereas leptin levels increased by 56% (P < 0.001) during 1 yr of insulin treatment and the increase in leptin preceded the increase in body weight. CONCLUSIONS: Significant correlations were observed between insulin's effect on serum leptin levels and the increase in weight that accompanied insulin therapy.
Anne-Marie Aas; Kristian F Hanssen; Jens Petter Berg; Per M Thorsby; Kåre I Birkeland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-09
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  94     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-06     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2900-6     Citation Subset:  AIM; IM    
Department of Nutrition and Dietetics, Aker University Hospital, Trondheimsveien 235, Oslo, Norway. a.m.aas@medisin
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MeSH Terms
Body Mass Index
Diabetes Mellitus, Type 2 / blood,  drug therapy*
Glucose / metabolism
Hemoglobin A, Glycosylated / analysis
Hypoglycemic Agents / therapeutic use
Insulin / pharmacology*,  therapeutic use
Leptin / blood*
Middle Aged
Signal Transduction
Weight Gain*
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 0/Leptin; 0/hemoglobin A1c protein, human; 11061-68-0/Insulin; 50-99-7/Glucose

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