| Insulin-stimulated increase in serum leptin levels precedes and correlates with weight gain during insulin therapy in type 2 diabetes. | |
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MedLine Citation:
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PMID:Â 19509109 Â Â Â Owner:Â NLM Â Â Â Status:Â MEDLINE Â Â Â |
Abstract/OtherAbstract:
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CONTEXT: Infusion of insulin acutely stimulates leptin production and chronic insulin treatment is associated with elevated serum leptin levels and body weight in subjects with type 2 diabetes. OBJECTIVE: The objective of the study was to investigate the relationship between insulin administration, leptin levels, and weight gain in subjects with type 2 diabetes. DESIGN: This was a post hoc analysis of two randomized, controlled trials. SETTING: The study was conducted at an outpatient clinic. SUBJECTS: Subjects included 35 (study 1) and 32 (study 2) poorly controlled oral hypoglycemic agent (OHA)-treated type 2 diabetic subjects. INTERVENTION: Study 1: subjects were investigated during a hyperinsulinemic, euglycemic glucose clamp and 12 months after being randomly allocated to start insulin or continue on OHAs. Study 2: 1 yr treatment with either OHAs and lifestyle intervention or insulin with or without concomitant lifestyle intervention. MAIN OUTCOME MEASURE: Changes in serum leptin levels during clamp and during 1 yr of treatment in relationship to changes in body weight. RESULTS: Study 1: during acute insulin infusion leptin levels increased by 10% (P < 0.001). During 1 yr of insulin therapy, mean body weight increased by 6%, whereas the fasting leptin levels increased by 108% (both P < 0.001). The weight gain observed at 1 yr correlated with the increase in leptin levels observed during the clamp (r = 0.62, P = 0.003). Study 2: mean body weight increased by 4% (P < 0.01), whereas leptin levels increased by 56% (P < 0.001) during 1 yr of insulin treatment and the increase in leptin preceded the increase in body weight. CONCLUSIONS: Significant correlations were observed between insulin's effect on serum leptin levels and the increase in weight that accompanied insulin therapy. |
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Authors:
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Anne-Marie Aas; Kristian F Hanssen; Jens Petter Berg; Per M Thorsby; KÃ¥re I Birkeland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't    Date: 2009-06-09 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism    Volume: 94    ISSN: 1945-7197    ISO Abbreviation: J. Clin. Endocrinol. Metab.    Publication Date: 2009 Aug |
Date Detail:
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Created Date:Â 2009-08-06 Â Â Â Completed Date:Â 2009-08-25 Â Â Â Revised Date:Â - Â Â Â |
Medline Journal Info:
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Nlm Unique ID: 0375362    Medline TA: J Clin Endocrinol Metab    Country: United States    |
Other Details:
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Languages: eng    Pagination: 2900-6    Citation Subset: AIM; IM    |
Affiliation:
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Department of Nutrition and Dietetics, Aker University Hospital, Trondheimsveien 235, Oslo, Norway. a.m.aas@medisin |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Mass Index Diabetes Mellitus, Type 2 / blood, drug therapy* Female Glucose / metabolism Hemoglobin A, Glycosylated / analysis Humans Hypoglycemic Agents / therapeutic use Insulin / pharmacology*, therapeutic use Leptin / blood* Male Middle Aged Signal Transduction Weight Gain* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 0/Leptin; 0/hemoglobin A1c protein, human; 11061-68-0/Insulin; 50-99-7/Glucose |
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