Document Detail


Insulin signalling to the kidney in health and disease.
MedLine Citation:
PMID:  23190266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ninety-one years ago insulin was discovered, which was one of the most important medical discoveries in the past century, transforming the lives of millions of diabetic patients. Initially insulin was considered only important for rapid control of blood glucose by its action on a restricted number of tissues; however, it has now become clear that this hormone controls an array of cellular processes in many different tissues. The present review will focus on the role of insulin in the kidney in health and disease.
Authors:
Lorna J Hale; Richard J M Coward
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  124     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-01-28     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Gluconeogenesis
Humans
Insulin / physiology*
Insulin Resistance / physiology
Kidney / physiology*
Kidney Glomerulus / physiology
Metabolic Syndrome X / physiopathology
Receptor, IGF Type 1 / physiology
Receptor, Insulin / physiology
Renal Circulation / physiology
Signal Transduction / physiology*
TOR Serine-Threonine Kinases / physiology
Grant Support
ID/Acronym/Agency:
G0501901//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
0/Insulin; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.10.1/Receptor, IGF Type 1; EC 2.7.10.1/Receptor, Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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