Document Detail

Insulin sensitivity with respect to glucose metabolism in hypertension-prone men did not predict the blood pressure increase in 5 years.
MedLine Citation:
PMID:  11687922     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate peripheral insulin stimulated glucose uptake as a predictor for increase in blood pressure in hypertension-prone men. DESIGN: A follow-up study 5 years after a primary investigation that included an euglycaemic hyperinsulinaemic clamp to evaluate insulin sensitivity. SUBJECTS: Thirty-two men with a family history of hypertension (relatives) and 22 men with no hypertension in the family (controls). All were normotensive and had a normal glucose tolerance. MAIN OUTCOME MEASURES: Change in blood pressure over 5 years and its relation to the values obtained in the basal investigation. RESULTS: Systolic and diastolic blood pressure increased in both groups during the 5 years, but diastolic blood pressure increased more in relatives than in controls (11 mm Hg vs 5 mm Hg, P = 0.03). The change in diastolic blood pressure was correlated to basal BMI (r = 0.43, P = 0.02) only in controls. There were no correlations between the change in blood pressure during the 5 years and basal glucose disposal nor to any of the other basal parameters in either relatives or controls. CONCLUSIONS: Insulin sensitivity did not predict the change in blood pressure during the 5 years either in hypertension-prone men or in controls, nor did anthropometrical measurements, basal and stimulated insulin and maximal oxygen uptake. The blood pressure increase was related to basal BMI only in controls.
I Mattiasson; T Endre; U L Hulthén
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  15     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-05     Completed Date:  2001-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  781-5     Citation Subset:  IM    
Department of Medicine, Malmö University Hospital, S-20502 Malmö, Sweden.
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MeSH Terms
Aldosterone / blood
Blood Glucose / metabolism*
Blood Pressure / physiology*
Body Mass Index
Family Health
Follow-Up Studies
Glucose Clamp Technique
Hypertension / diagnosis,  epidemiology,  metabolism*
Insulin Resistance / physiology*
Logistic Models
Middle Aged
Oxygen / blood
Predictive Value of Tests
Sensitivity and Specificity
Reg. No./Substance:
0/Blood Glucose; 52-39-1/Aldosterone; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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