Document Detail

Insulin sensitivity, sympathetic activity, and cardiovascular reactivity in young men.
MedLine Citation:
PMID:  7794576     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to examine the relationships between insulin sensitivity, blood pressure (BP), and cardiovascular reactivity, and to assess sympathetic nervous system influence. Insulin sensitivity (GDR/I; euglycemic glucose clamp technique) was related to BP and heart rate (HR) in different situations in 40 healthy young men: in the laboratory, during a mental arithmetic stress test, and during baseline conditions at home. GDR/I correlated with supine diastolic BP in the laboratory and with maximum diastolic BP during mental stress (r = -0.46, P = .003; r = -0.62, P = .0001, respectively), but not so strongly with diastolic BP measured at home (r = -0.29, P = .09). Diastolic BP during stress and body mass index were the only independent explanatory variables of GDR/I in multiple regression analysis (multiple R = 0.71, R2 = 0.50, P < .0001). GDR/I and systolic BP were not significantly correlated at any time. GDR/I correlated negatively with HR in the laboratory and with maximum HR during mental stress, but not with HR at home. Maximum plasma epinephrine during stress correlated with stress BP and HR (r = 0.53, P = .001; r = 0.70, P < .0001, respectively) and negatively with GDR/I (r = -0.36, P < .05). In the present study, GDR/I is related to diastolic but not to systolic BP, and more closely correlated to diastolic BP and HR measured during mental stress than to diastolic BP and HR during baseline conditions at home.(ABSTRACT TRUNCATED AT 250 WORDS)
A Moan; G Nordby; M Rostrup; I Eide; S E Kjeldsen
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  8     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-03     Completed Date:  1995-08-03     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  268-75     Citation Subset:  IM    
Department of Internal Medicine, Ullevaal Hospital, University of Oslo, Norway.
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MeSH Terms
Blood Pressure / drug effects
Body Weight
Catecholamines / blood
Heart Rate / drug effects
Hemodynamics / drug effects*
Insulin / pharmacology*
Insulin Resistance*
Lipids / blood
Stress, Psychological / blood
Sympathetic Nervous System / drug effects*
Reg. No./Substance:
0/Catecholamines; 0/Lipids; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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