Document Detail

Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women.
MedLine Citation:
PMID:  15897479     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether macronutrient composition of a hypocaloric diet can enhance its effectiveness and whether insulin sensitivity (Si) affects the response to hypocaloric diets. RESEARCH METHODS AND PROCEDURES: Obese nondiabetic insulin-sensitive (fasting insulin < 10 microU/mL; n = 12) and obese nondiabetic insulin-resistant (fasting insulin > 15 microU/mL; n = 9) women (23 to 53 years old) were randomized to either a high carbohydrate (CHO) (HC)/low fat (LF) (60% CHO, 20% fat) or low CHO (LC)/high fat (HF) (40% CHO, 40% fat) hypocaloric diet. Primary outcome measures after a 16-week dietary intervention were: changes in body weight (BW), Si, resting metabolic rate, and fasting lipids. RESULTS: Insulin-sensitive women on the HC/LF diet lost 13.5 +/- 1.2% (p < 0.001) of their initial BW, whereas those on the LC/HF diet lost 6.8 +/- 1.2% (p < 0.001; p < 0.002 between the groups). In contrast, among the insulin-resistant women, those on the LC/HF diet lost 13.4 +/- 1.3% (p < 0.001) of their initial BW as compared with 8.5 +/- 1.4% (p < 0.001) lost by those on the HC/LF diet (p < 0.04 between two groups). These differences could not be explained by changes in resting metabolic rate, activity, or intake. Overall, changes in Si were associated with the degree of weight loss (r = -0.57, p < 0.05). DISCUSSION: The state of Si determines the effectiveness of macronutrient composition of hypocaloric diets in obese women. For maximal benefit, the macronutrient composition of a hypocaloric diet may need to be adjusted to correspond to the state of Si.
Marc-Andre Cornier; W Troy Donahoo; Rocio Pereira; Inga Gurevich; Rickard Westergren; Sven Enerback; Peter J Eckel; Marc L Goalstone; James O Hill; Robert H Eckel; Boris Draznin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obesity research     Volume:  13     ISSN:  1071-7323     ISO Abbreviation:  Obes. Res.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-17     Completed Date:  2005-11-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9305691     Medline TA:  Obes Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-9     Citation Subset:  IM    
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA.
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MeSH Terms
Basal Metabolism
Body Mass Index
Diet, Reducing*
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Energy Intake
Energy Metabolism
Insulin / blood
Insulin Resistance*
Middle Aged
Obesity / physiopathology,  therapy*
Treatment Outcome
Weight Loss*
Grant Support
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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