| Insulin sensitivity and blood pressure in a biethnic sample: the Miami Community Health Study. | |
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MedLine Citation:
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PMID: 8699204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An association between blood pressure and insulin sensitivity among normotensive African-Americans has not been demonstrated consistently in epidemiologic studies. Part of the discrepancy may be due to studying persons with profound obesity-an insulin-resistant state itself. The association between insulin-mediated glucose uptake (i.e., insulin sensitivity) and blood pressure was examined among 25 nondiabetic African-American and 28 white non-Hispanic persons aged 25-44 years who ranged from normal weight to obese, using the hyperinsulinemic euglycemic clamp technique. In bivariate analyses, insulin sensitivity was inversely related to systolic (p < 0.01) and diastolic blood pressure (p = 0.08) among African-American persons and to diastolic blood pressure among white non-Hispanic subjects (p < 0.05). Covariate adjustment for age and sex had only a marginal effect on these results. When the data were pooled and further adjusted for ethnicity, insulin sensitivity remained significantly associated with both systolic and diastolic blood pressure (p < 0.01 for each). To consider the effect of obesity, body mass index (BMI) was divided at the sample median (26.5 kg/m2) and the analyses were repeated within each stratum. Among those whose BMI was below the median value, each increment in insulin sensitivity was associated with a 2-mmHg decrease in systolic blood pressure (p = 0.02). These results suggest that ethnicity was not a strong effect modifier in this sample and indicated that insulin sensitivity was inversely related to blood pressure level in these normotensive African-American and white, non-Hispanic participants. |
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Authors:
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R P Donahue; R A Donahue; R J Prineas; J Bean; M Gutt; J S Skyler; N Schneiderman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of clinical epidemiology Volume: 49 ISSN: 0895-4356 ISO Abbreviation: J Clin Epidemiol Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-09-04 Completed Date: 1996-09-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8801383 Medline TA: J Clin Epidemiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 859-64 Citation Subset: IM |
Affiliation:
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University of Miami School of Medicine, Department of Epidemiology and Public Health, Florida 33136, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group* Blood Glucose / metabolism* Blood Pressure / physiology* Body Mass Index Female Humans Insulin / blood* Insulin Resistance Male Obesity / blood, ethnology Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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HL-44600/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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