Document Detail


Insulin sensitivity and Lp(a) concentrations in normoglycemic men.
MedLine Citation:
PMID:  7729297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Increased lipoprotein(a) [Lp(a)] concentrations have been recognized as a risk factor for coronary heart disease. Little data exists on the relationship of Lp(a) concentrations to insulin resistance. RESEARCH DESIGN AND METHODS: We examined insulin resistance (as determined by the euglycemic clamp) together with indirect calorimetry in relation to Lp(a) concentrations, apolipoprotein(a) [apo(a)] molecular weight, and apo(a) phenotype in 87 normoglycemic men. RESULTS: Lp(a) concentrations were significantly related to total (r = 0.225) and nonoxidative (r = 0.256) whole-body glucose disposal. These results suggest a positive but weak association between insulin sensitivity (restricted to the nonoxidative whole-body glucose disposal) and Lp(a) concentrations. However, after adjustment for apo(a) molecular weight [which accounts for some of the genetic influences on Lp(a) levels], total and nonoxidative body glucose disposal were not significantly related to Lp(a) concentrations. CONCLUSIONS: Normoglycemic insulin-resistant subjects do not have elevated Lp(a) concentrations.
Authors:
S M Haffner; P Karhapaa; D L Rainwater; L Mykkanen; G Aldrete; M Laakso
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes care     Volume:  18     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-30     Completed Date:  1995-05-30     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7873, USA.
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MeSH Terms
Descriptor/Qualifier:
Apolipoproteins / blood
Apoprotein(a)
Blood Glucose / metabolism*
Body Mass Index
C-Peptide / blood
Calorimetry
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Fasting
Glucose / metabolism
Glucose Clamp Technique
Humans
Insulin / blood
Insulin Resistance*
Lipoprotein(a) / blood*
Male
Middle Aged
Phenotype
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
HL-40637/HL/NHLBI NIH HHS; R01-HL-24799/HL/NHLBI NIH HHS; R37-HL-36820/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Blood Glucose; 0/C-Peptide; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoprotein(a); 0/Triglycerides; 11061-68-0/Insulin; 50-99-7/Glucose; 57-88-5/Cholesterol; EC 3.4.21.-/Apoprotein(a)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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