| Insulin-sensitive obesity in humans - a 'favorable fat' phenotype? | |
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MedLine Citation:
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PMID: 22284531 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In most humans, obesity and insulin resistance coexist. However, a unique group of obese individuals, who exhibit better insulin sensitivity than expected for their adiposity, has been the focus of recent research interest. We critically examine cross-sectional and lifestyle intervention studies in obese humans classified as 'insulin-sensitive' versus 'insulin-resistant' and review the few longitudinal studies comparing rates of cardiovascular disease, type 2 diabetes and all-cause mortality in these groups of individuals. We suggest that reduced deposition of fat, particularly of bioactive lipid intermediates, in muscle and liver is potentially protective. We propose that dynamic interventional studies in insulin-sensitive obese humans may increase understanding of the metabolic factors that play a role in obesity-associated insulin resistance in humans. |
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Authors:
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D Samocha-Bonet; D J Chisholm; K Tonks; L V Campbell; J R Greenfield |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: - ISSN: 1879-3061 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia; Faculty of Medicine, University of New South Wales, Sydney 2052, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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