| Insulin secretion, nutritional status and respiratory function in cystic fibrosis patients with normal glucose tolerance. | |
| | |
MedLine Citation:
|
PMID: 21974813 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: Impaired growth and nutritional status in CF may be related to progressive insulin deficiency before CF-Related Diabetes has established. Aim of this study was to analyse the association of circulating insulin with nutritional status and lung function in CF patients with normal glucose tolerance (NGT). METHODS: We performed OGTT in 152 consecutive CF patients aged 8-20 years: 115 of them had NGT and were included in the study. Areas under the curves (AUC) of glucose, insulin and c-peptide after 120 min were calculated. Quartiles (Q) of increasing fasting insulin (fINS-Q) and c-peptide (fCP-Q) levels were calculated in CF patients. Respiratory function parameters (FEV1, FVC), Standard Deviation Scores (SDS) of height, weight and BMI were compared between Q1 and the three higher Q. Multiple regression analysis was used to analyse the association of fasting insulin, c-peptide or OGTT derived indices with nutritional or respiratory parameters. RESULTS: Compared to patients in fINS-Q4 or fCP-Q4, those in fINS-Q1 or in fCP-Q1 respectively showed lower levels of insulin AUC or c-peptide AUC (both P < 0.0001), weight-SDS (P = 0.013, P = 0.007), BMI-SDS (P = 0.010, P = 0.002), FEV1 (P = 0.076, P = 0.013) and FVC (P = 0.101, P = 0.009). Age- and gender-adjusted regression analysis showed significant associations of fINS and fCP with SDS of BMI (P = 0.023 and P = 0.001 respectively), fCP was significant associated with FEV1 (P = 0.01). AUC insulin/AUC glucose ratio (P < 0.0001) and AUC c-peptide/AUC glucose ratio (P = 0.0001) were significantly associated with FEV1. CONCLUSIONS: Insulin deficiency in CF patients with NGT has a significant impact on clinical outcomes. |
| | |
Authors:
|
Gianfranco Alicandro; Pier Maria Battezzati; Alberto Battezzati; Chiara Speziali; Laura Claut; Valentina Motta; Silvana Loi; Carla Colombo |
Related Documents
:
|
11988243 - Patients with multiple sclerosis and risk of type 1 diabetes mellitus in sardinia, ital... 11880933 - Diabetes mellitus and its complications in a hungarian population. 22223763 - Update in the cns response to hypoglycemia. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-3 |
Journal Detail:
|
Title: Clinical nutrition (Edinburgh, Scotland) Volume: - ISSN: 1532-1983 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
|
Department of Paediatrics, Cystic Fibrosis Center of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Via Commenda 9, 20122 Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A prospective study of catheter-related complications in HPN patients.
Next Document: Single-center experience with levosimendan in children undergoing cardiac surgery and in children wi...