| Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals. | |
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MedLine Citation:
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PMID: 18551117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabolically obese but normal-weight (MONW) individuals present metabolic disturbances typical of obese individuals. Additionally, metabolically healthy but obese (MHO) individuals have been identified who are relatively insulin sensitive and have a favorable cardiovascular risk profile. We compared insulin secretion patterns of MONW and MHO with those of two age-matched groups comprising nonobese individuals or obese insulin-resistant subjects, respectively. To this end, 110 nonobese subjects and 87 obese subjects were stratified into quartile based on their insulin-stimulated glucose disposal (M(FFM)). Insulin secretion was estimated by acute insulin response (AIR) during an intravenous glucose-tolerance test (IVGTT), and the disposition index was calculated as AIR x M(FFM). We found that, as defined, M(FFM) was lower in MONW, who exhibited higher triglycerides, free-fatty acid (FFA), and 2-h postchallenge glucose levels compared to normal nonobese group. Insulin secretion was higher in MONW than in normal nonobese subjects, but disposition index was lower in MONW. Disposition index did not differ between MONW and insulin-resistant obese. M(FFM) was higher in MHO who exhibited lower waist circumference, blood pressure (BP), triglycerides, FFA, insulin levels, and higher high-density lipoprotein (HDL) cholesterol compared to insulin-resistant obese. Insulin secretion did not differ between insulin-resistant obese and MHO, but disposition index was lower in the former group. In conclusion, MONW and insulin-resistant obese showed decreased compensatory insulin secretion compared to normal nonobese and MHO subjects, respectively. Because these subjects also exhibited a worse metabolic risk profile, these findings may account for their increased risk for type 2 diabetes. |
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Authors:
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Elena Succurro; Maria A Marini; Simona Frontoni; Marta L Hribal; Francesco Andreozzi; Renato Lauro; Francesco Perticone; Giorgio Sesti |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-12 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 16 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-01 Completed Date: 2008-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1881-6 Citation Subset: IM |
Affiliation:
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1Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism Body Weight / physiology* Cross-Sectional Studies Diabetes Mellitus, Type 2 / epidemiology Fatty Acids, Nonesterified / blood Female Humans Insulin / blood, secretion* Insulin Resistance / physiology Male Obesity / blood*, physiopathology* Risk Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Triglycerides; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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