Document Detail

Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats: relevance to sporadic Alzheimer's disease?
MedLine Citation:
PMID:  21136123     Owner:  NLM     Status:  In-Data-Review    
An insulin-resistant brain state (IRBS) was induced by intracerebroventricular application of the diabetogenic substance streptozotocin (STZ) to investigate changes in cerebral fatty acids. Six weeks after the first STZ injection, increases were found in the concentrations of palmitic and stearic acid in temporal cortex; and of palmitic acid in entorhinal cortex indicative of membrane phospholipid breakdown, and damage of the membrane structure. The relevance of these changes is discussed in relation to sporadic Alzheimer's disease.
Konstanze Plaschke; Dorothea Müller; Siegfried Hoyer
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Publication Detail:
Type:  Journal Article     Date:  2010-12-07
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  117     ISSN:  1435-1463     ISO Abbreviation:  J Neural Transm     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1419-22     Citation Subset:  IM    
Department of Anesthesiology, Experimental Anesthesiology, Medical Faculty of the University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany,
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