Document Detail

Insulin-resistant Na+ pump activity in adipocytes from obese humans.
MedLine Citation:
PMID:  2411146     Owner:  NLM     Status:  MEDLINE    
Basal and maximally insulin-stimulated Na+-pump activity was measured in adipocytes from subjects with normal glucose tolerance over a range of body mass indexes (BMI). In a comparison of 13 lean (BMI less than 25) vs. 15 extremely obese (BMI greater than 40) subjects basal activities per unit surface area were similar, but the maximally insulin-stimulated activity was significantly reduced in the extremely obese group [9.2 +/- 0.6 vs. 12.1 +/- 1.0 (min X dam2)-1, P less than 0.05]. The mean percent insulin stimulation of the Na+ pump above basal activity was 48 +/- 7% for the lean compared with 14 +/- 2% for the extremely obese group (P less than 0.001). A similar relationship was observed in these subjects for glucose transport where basal activities per unit surface area again were similar but the maximally insulin-stimulated transport was reduced in the extremely obese subjects (2.2 +/- 0.3 vs 5.1 +/- 0.6 attol/um2 X s, P less than 0.001). These results indicate that alterations in Na+-pump activity may be a manifestation of the insulin-resistant state that could contribute to the development of obesity via decreased cellular thermogenesis.
D M Mott; R L Clark; W J Andrews; J E Foley
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  249     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-11     Completed Date:  1985-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E160-4     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism*
European Continental Ancestry Group
Glucose / metabolism
Indians, North American
Insulin Resistance*
Ion Channels / drug effects*
Middle Aged
Obesity / metabolism*
Ouabain / pharmacology
Radioisotopes / diagnostic use
Rubidium / diagnostic use
Sodium / metabolism*
Reg. No./Substance:
0/Ion Channels; 0/Radioisotopes; 50-99-7/Glucose; 630-60-4/Ouabain; 7440-17-7/Rubidium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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