| Insulin resistance and vitamin D deficiency in patients with chronic kidney disease stage 2-3. | |
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MedLine Citation:
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PMID: 20945958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3. Insulin sensitivity/resistance was calculated by the quantitative insulin sensitivity check index (QUICKI). In this analysis, the prevalence of insulin resistance was 42 %. Only 17 % of patients had serum 25(OH) vitamin D concentration in the recommended range (>/=30 ng/ml), 42 % suffered from vitamin D insufficiency and 41 % had moderate vitamin D deficiency. Insulin resistance significantly correlated with serum 25(OH)D and 1,25(OH)(2)D concentrations, renal function and protein excretion rate. Our results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease. |
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Authors:
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K Stefíková; V Spustová; Z Krivošíková; A Okša; K Gazdíková; V Fedelešová; R Dzúrik |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-15 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 60 ISSN: 1802-9973 ISO Abbreviation: Physiol Res Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2011-08-09 Revised Date: 2011-10-21 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 149-55 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, Bratislava, Slovakia. kornelia.stefikova@szu.sk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Mass Index Female Humans Insulin Resistance / physiology* Male Middle Aged Renal Insufficiency, Chronic / complications*, metabolism Vitamin D / blood* Vitamin D Deficiency / blood, complications*, epidemiology |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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