| Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men. | |
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MedLine Citation:
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PMID: 11522711 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate whether cardiovascular risk factors cluster with hyperinsulinemia in elderly type 2 diabetic subjects and, if so, whether this clustering predicts coronary heart disease (CHD) events during a 7-year follow-up. RESEARCH DESIGN AND METHODS: Clustering of cardiovascular risk factors was analyzed by factor analysis. Cox regression models were used to investigate whether these clusters (factors) predict CHD events (CHD death or nonfatal myocardial infarction) during a 7-year follow-up in 229 type 2 diabetic subjects aged 65-74 years. RESULTS: There were 70 CHD events (21 in men and 49 in women) during the follow-up period. In diabetic men, components of the insulin resistance syndrome (IRS) loaded on Factor 1 (the insulin resistance factor), which reflected high fasting insulin, obesity (high BMI), central obesity (high waist-to-hip ratio), high total triglycerides, and a short duration of diabetes. Only this IRS factor predicted CHD events in multivariate Cox regression analysis (hazard ratio [HR] 1.71, 95% CI 1.08-2.71, P = 0.022). In diabetic women, components of IRS loaded on two factors, none of which predicted CHD events. In women, only Factor 4, characterized by advanced age, left ventricular hypertrophy on electrocardiogram, high alcohol consumption, high systolic blood pressure, and albuminuria, predicted CHD events in multivariate Cox regression analysis (1.34, 1.03-1.74, P = 0.03). CONCLUSIONS: IRS is a risk factor for CHD in elderly type 2 diabetic men. |
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Authors:
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J Kuusisto; P Lempiäinen; L Mykkänen; M Laakso |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes care Volume: 24 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-08-27 Completed Date: 2001-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 1629-33 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Kuopio, FIN-70211 Kuopio, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alcohol Drinking Blood Glucose / metabolism Blood Pressure Body Mass Index Chest Pain / epidemiology Cholesterol / blood Cholesterol, HDL / blood Cohort Studies Coronary Disease / epidemiology*, physiopathology Diabetes Mellitus, Type 2 / blood, complications, physiopathology* Diabetic Angiopathies / epidemiology, physiopathology Electrocardiography Female Follow-Up Studies Humans Hypertension / epidemiology Insulin / blood Insulin Resistance / physiology* Longitudinal Studies Male Proportional Hazards Models Questionnaires Regression Analysis Risk Factors Sex Characteristics Smoking Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, HDL; 11061-68-0/Insulin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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