| Insulin resistance, prehypertension, hypertension and blood pressure values in paediatric age. | |
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MedLine Citation:
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PMID: 22179078 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: The aim of the present study was to evaluate whether insulin resistance [as measured by Homeostasis Model Assessment (HOMA) index] has an effect on prehypertension and hypertension risk in children after acknowledging the role of BMI and waist-to-height ratio. METHODS:: We studied a sample of 377 children 10.5 ± 2.3 years old who had a first diagnosis of hypertension or family history of cardiovascular disease. In this sample all weight classes were represented. The HOMA index was standardized by a linear regression model including BMI, waist-to-height ratio and pubertal status. RESULTS:: The role of BMI and waist-to-height ratio on the risk of prehypertension and hypertension was confirmed by univariate logistic regression models, odds ratio of 1.59 [95% confidence interval (CI) = 1.27-2.00] for BMI, and 1.56 (95% CI = 1.06-2.31) for waist-to-height ratio (>50 vs. ≤50%). When standardized HOMA index was added to BMI or waist-to-height ratio in a multivariate model, it gave a significant independent contribution to explain the risk of prehypertension and hypertension. Odds ratio was 1.23 (95% CI = 1.01-1.51) in the model with BMI, and 1.23 (95% CI = 1.01-1.50) in the model with waist-to-height ratio. The role of HOMA index was confirmed when continuous values of systolic and diastolic blood pressure (standardized by age, sex and height) were analysed, instead of hypertension category. CONCLUSIONS:: These results strongly support the hypothesis that in children, insulin resistance plays a role on hypertension independently from obesity, fat distribution and puberty across weight classes. |
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Authors:
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Simonetta Genovesi; Paolo Brambilla; Marco Giussani; Sara Galbiati; Silvana Mastriani; Federico Pieruzzi; Andrea Stella; Maria Grazia Valsecchi; Laura Antolini |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-15 |
Journal Detail:
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Title: Journal of hypertension Volume: - ISSN: 1473-5598 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aDepartment of Clinical Medicine and Prevention, University of Milano-Bicocca and Nephrology Unit, San Gerardo Hospital, Monza bFamily Paediatrician, Milano cDepartment of Clinical Medicine and Prevention, Centre of Biostatistics for Clinical Epidemiology, University of Milano-Bicocca, Monza, Italy. |
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