| Insulin resistance and overweight-obese women with polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 19903118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To estimate (1) the prevalence of insulin resistance (IR) by fasting glucose: insulin ratio (G:I) (G:I <or= 4.5) in overweight-obese polycystic ovary syndrome (PCOS) women, (2) to compare the clinical and biochemical parameters between insulin-resistant and insulin-sensitive groups. MATERIALS AND METHODS: Eighty-one overweight-obese PCOS women (body mass index (BMI) >or= 23 kg/m(2)) were studied. PCOS was diagnosed as per the Rotterdam 2003 criteria. BMI, abdominal circumference (AC), hirsutism (Ferriman Gallway score >or=6), presence of acne and acanthosis nigricans (AN) were noted in each case. Serum testosterone, sex hormone binding globulin (SHBG), fasting plasma glucose and insulin levels were measured. RESULTS: 23.5% women were found to have IR. There were no differences in age, frequency of hirsutism, acne, serum testosterone and fasting glucose levels between insulin-resistant and insulin-sensitive women. However, there were significant differences in BMI, AC, frequency of AN, SHBG levels, fasting insulin levels and FAI between the two groups. CONCLUSION: PCOS women with IR are more obese; they have more upper body adiposity and AN. They are more hyperandrogenic. Simple clinical parameters will help to suspect IR in PCOS women. |
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Authors:
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Sudhindra Mohan Bhattacharya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-07-22 Revised Date: 2011-04-14 |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 344-7 Citation Subset: IM |
Affiliation:
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S C Das Memorial Medical & Research Center, Kolkata, India. drsudhindra54@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acanthosis Nigricans
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epidemiology Adolescent Adult Blood Glucose / analysis Body Mass Index Fasting Female Humans Insulin / blood Insulin Resistance* Obesity / complications* Overweight / complications* Polycystic Ovary Syndrome / blood, complications*, diagnosis Sex Hormone-Binding Globulin / analysis Testosterone / blood Waist Circumference |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Sex Hormone-Binding Globulin; 11061-68-0/Insulin; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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