| Insulin resistance and other metabolic risk factors in the pathogenesis of hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 21689613 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Coinciding with the increased incidence of hepatocellular carcinoma (HCC), there has been a significant increase in the global incidence of obesity and diabetes mellitus (DM), the two major risk factors for nonalcoholic steatohepatitis (NASH). There are many causes of HCC, and nonalcoholic fatty liver disease/NASH is now emerging as a leading risk factor owing to the epidemic of obesity and type 2 DM. The mechanisms leading to HCC in obesity and type 2 DM likely involve interactions between several signaling pathways, including oxidative stress, inflammation, oncogenes, adiponectins, and insulin resistance associated with visceral adiposity and diabetes. |
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Authors:
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Asma Siddique; Kris V Kowdley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinics in liver disease Volume: 15 ISSN: 1557-8224 ISO Abbreviation: Clin Liver Dis Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-06-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9710002 Medline TA: Clin Liver Dis Country: United States |
Other Details:
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Languages: eng Pagination: 281-96 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Liver Disease, Virginia Mason Medical Center, Digestive Disease Institute, 1100 Ninth Avenue, PO Box 900, Seattle, WA 98111, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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