| Insulin resistance and metabolic syndrome in prepubertal boys with Klinefelter syndrome. | |
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MedLine Citation:
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PMID: 21251059 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: To investigate risk factors for metabolic syndrome in prepubertal boys with Klinefelter syndrome. Methods: 89 boys with Klinefelter syndrome, ages 4-12.9 years, and 34 age-matched control boys had height, weight, waist circumference and blood pressure measured and their parents completed a questionnaire about physical activity. The boys with Klinefelter syndrome also had measurement of lipids, fasting glucose and insulin. Insulin-glucose homeostasis model assessment was calculated, and the boys were evaluated for childhood metabolic syndrome. Results: The Klinefelter syndrome and control groups were similar ages (7.5 2.4 vs. 8.1 2.3 yrs). Body mass index measurements were similar, but waist circumference was >90%ile in 30% of boys with Klinefelter syndrome versus 21% of controls. The mean daily time spent running was 42 minutes less in the Klinefelter syndrome vs. control groups (P < 0.01). 37% of the boys with Klinefelter syndrome had elevated LDL cholesterol, 24% had insulin resistance, and 7% met the three criteria for diagnosis of metabolic syndrome. Conclusions: Truncal obesity, insulin resistance, and metabolic syndrome are present in boys as young as 4-12 years with Klinefelter syndrome, and these occur in association with reduced running type activity. |
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Authors:
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Martha Zeger Bardsley; Bonita Falkner; Karen Kowal; Judith L Ross |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-19 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Foundation Acta Paediatrica. |
Affiliation:
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Pediatrics, Thomas Jefferson University/Nemours, Philadelphia, PA, United States, 19107 Pediatrics and Medicine, Thomas Jefferson University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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