| Insulin resistance influences weight loss in non-obese women who followed a home-based exercise program and slight caloric restriction. | |
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MedLine Citation:
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PMID: 21466903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed to evaluate the influence of insulin resistance status on weight changes in non-obese women who followed a home-based exercise program and slight caloric restriction over a period of 12 months. Middle-aged (25-45 year), non-obese (body mass index of 23-29.9 kg/m(2)) women were randomly assigned to control (CG) or home-based exercise group (HB). The HB group received a booklet explaining the physical exercises to be practiced at home at least three times per week (40 min/session). Both groups were required to follow a small energy restriction of 100-300 calories per day. For the analysis, women were stratified in two groups according to baseline insulin sensitivity: NIR (non-insulin resistant; n = 121) and IR (insulin resistant; n = 64). Women classified as IR at baseline had greater weight loss after 12 months of follow-up (-1.6 kg vs. -1.1 kg; p = 0.01), and HB exercise helped to reduce weight only among NIR women (-1.5 vs. -0.7; p = 0.04); no differences were observed between intervention groups for IR women (-1.5 vs. -1.7; p = 0.24). There were no differences between IR and NIR groups for lipid profile after adjustment for weight changes. Insulin resistance facilitated weight loss, and home-based exercise promoted greater weight loss only in non-insulin resistance women. |
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Authors:
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Mauro Felippe Felix Mediano; Rosely Sichieri |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-04-03 |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 92 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-07 Completed Date: 2011-10-17 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 361-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Clinical and Experimental Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil. mffmediano@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Caloric Restriction* Exercise Therapy / methods* Female Humans Insulin Resistance / physiology* Middle Aged Weight Loss / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R03 TW005773-01/TW/FIC NIH HHS; R03 TW005773-02/TW/FIC NIH HHS; R03 TW005773-03/TW/FIC NIH HHS; R03 TW005773-03/TW/FIC NIH HHS |
| Comments/Corrections | |
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