Document Detail

Insulin resistance influences weight loss in non-obese women who followed a home-based exercise program and slight caloric restriction.
MedLine Citation:
PMID:  21466903     Owner:  NLM     Status:  MEDLINE    
This study aimed to evaluate the influence of insulin resistance status on weight changes in non-obese women who followed a home-based exercise program and slight caloric restriction over a period of 12 months. Middle-aged (25-45 year), non-obese (body mass index of 23-29.9 kg/m(2)) women were randomly assigned to control (CG) or home-based exercise group (HB). The HB group received a booklet explaining the physical exercises to be practiced at home at least three times per week (40 min/session). Both groups were required to follow a small energy restriction of 100-300 calories per day. For the analysis, women were stratified in two groups according to baseline insulin sensitivity: NIR (non-insulin resistant; n = 121) and IR (insulin resistant; n = 64). Women classified as IR at baseline had greater weight loss after 12 months of follow-up (-1.6 kg vs. -1.1 kg; p = 0.01), and HB exercise helped to reduce weight only among NIR women (-1.5 vs. -0.7; p = 0.04); no differences were observed between intervention groups for IR women (-1.5 vs. -1.7; p = 0.24). There were no differences between IR and NIR groups for lipid profile after adjustment for weight changes. Insulin resistance facilitated weight loss, and home-based exercise promoted greater weight loss only in non-insulin resistance women.
Mauro Felippe Felix Mediano; Rosely Sichieri
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-03
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  92     ISSN:  1872-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-07     Completed Date:  2011-10-17     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  361-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Caloric Restriction*
Exercise Therapy / methods*
Insulin Resistance / physiology*
Middle Aged
Weight Loss / physiology*
Grant Support
R03 TW005773/TW/FIC NIH HHS; R03 TW005773-01/TW/FIC NIH HHS; R03 TW005773-02/TW/FIC NIH HHS; R03 TW005773-03/TW/FIC NIH HHS; R03 TW005773-03/TW/FIC NIH HHS

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