| Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients. | |
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MedLine Citation:
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PMID: 20130937 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In addition to chronic hyperglycemia, insulin resistance itself has been proposed to cause a diabetic neuropathy. We evaluated the role of insulin resistance in the pathogenesis of peripheral and autonomic neuropathy in patients with type 2 diabetes. Eighty-six patients with type 2 diabetes were evaluated for the anthropometric and biochemical profiles, and Kitt value was calculated from insulin tolerance test to assess the insulin resistance. Various autonomic function tests, nerve conduction velocity, and quantitative sensory tests were performed to assess autonomic and peripheral neuropathy. In univariate analysis, both autonomic and peripheral neuropathy were significantly associated with glycemic exposure index (GE index), HDL-cholesterol, duration of DM, and Kitt value. In stepwise linear regression analysis, GE index was an independent predictor of autonomic and peripheral neuropathy (β = 0.643, P < 0.001; β = 0.207, P = 0.013, respectively), and Kitt value was also an independent factor for the autonomic and peripheral neuropathy (β = - 0.306, P < 0.001; β = - 0.329, P < 0.001, respectively). Low HDL-cholesterol increased the odds ratio for peripheral neuropathy. Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean Type 2 diabetic patients along with hyperglycemia and HDL-cholesterol. |
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Authors:
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Kee Ook Lee; Ji Sun Nam; Chul Woo Ahn; Ji-Man Hong; Seung-Min Kim; Il-Nam Sunwoo; Joon-Shik Moon; Sang-Jun Na; Young-Chul Choi |
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Publication Detail:
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Type: Journal Article Date: 2010-02-04 |
Journal Detail:
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Title: Acta diabetologica Volume: 49 ISSN: 1432-5233 ISO Abbreviation: Acta Diabetol Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200299 Medline TA: Acta Diabetol Country: Germany |
Other Details:
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Languages: eng Pagination: 97-103 Citation Subset: IM |
Affiliation:
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Department of Neurology, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-Gu, Seoul, 135-720, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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