Document Detail

Insulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle.
MedLine Citation:
PMID:  9535149     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether insulin-stimulated blood flow in patients with mild essential hypertension is altered. SUBJECTS: Eleven untreated mildly hypertensive patients [aged 35 +/- 2 years, body mass index 25.1 +/- 0.4 kg/m2, mean arterial pressure 110 +/- 2 mmHg (means +/- SEM) and 10 matched normotensive subjects (mean arterial pressure 94 +/- 3 mmHg). METHODS: Blood flow was quantitated directly in skeletal muscle both basally and during supraphysiologic hyperinsulinemia (serum insulin approximately = 450 mU/l) using radiowater ([15O]H2O) and positron emission tomography. Whole-body and femoral muscle glucose uptakes were determined using the euglycemic insulin clamp technique, [18F]-2-fluoro-2-deoxy-D-glucose and positron emission tomography. RESULTS: Rates of whole-body and femoral muscle glucose uptake were significantly lower in the hypertensive than in the normotensive group. Insulin increased muscle blood flow by 91% in the normotensive group, but only by 33% in the hypertensive group. CONCLUSIONS: The ability of insulin to stimulate blood flow in patients with mild essential hypertension is impaired.
H Laine; M J Knuuti; U Ruotsalainen; M Raitakari; H Iida; J Kapanen; O Kirvelä; M Haaparanta; H Yki-Järvinen; P Nuutila
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  16     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-28     Completed Date:  1998-05-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  211-9     Citation Subset:  IM    
Department of Medicine, University of Turku, Finland.
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MeSH Terms
Blood Glucose / metabolism
Glucose / metabolism
Glucose Clamp Technique
Hypertension / physiopathology*
Insulin / blood,  pharmacology*,  physiology
Insulin Resistance / physiology*
Muscle, Skeletal / blood supply*
Regional Blood Flow / drug effects,  physiology
Tomography, Emission-Computed
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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