Document Detail

Insulin resistance in cirrhosis: evidence for a post-receptor defect.
MedLine Citation:
PMID:  6391747     Owner:  NLM     Status:  MEDLINE    
Receptor and post-receptor abnormalities of insulin action and their possible role in the insulin resistance of cirrhosis were examined in eight biopsy-proven cirrhotic subjects and eight age-weight matched healthy volunteers. To this end, oral glucose tolerance tests (OGTT), insulin dose response curves and insulin binding to circulating monocytes were determined for each subject. The dose-response curves for the cirrhotic subjects were significantly shifted to the right compared to the control subjects, indicating the presence of insulin insensitivity (ED50 223 +/- 30 versus 64 +/- 8 mU/l respectively; P less than 0.001). The magnitude of the right shift of the insulin-dose response curves correlated significantly (P less than 0.001) with the OGTT 2 h insulin levels (r = 0.74) and the insulin areas under the OGTT curves (r = 0.86). In contrast, insulin responsiveness was marginally elevated in the cirrhotic group (maximal glucose disposal 680 +/- 47 versus 574 +/- 21 ml/m2/min; P less than 0.05). Insulin binding to circulating monocytes was normal in the cirrhotic subjects. It is concluded that the insulin resistance of cirrhosis is due to a post-receptor defect in insulin action which reduces insulin sensitivity but not insulin responsiveness.
J Proietto; A Nankervis; P Aitken; F J Dudley; G Caruso; F P Alford
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical endocrinology     Volume:  21     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-02-11     Completed Date:  1985-02-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  677-88     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / metabolism
Dose-Response Relationship, Drug
Glucose Tolerance Test
Insulin / blood,  pharmacology
Insulin Resistance*
Liver Cirrhosis / blood*
Middle Aged
Monocytes / metabolism
Receptor, Insulin / metabolism
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; EC, Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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